两种常用根除幽门螺杆菌三联方案的疗效观察  

Comparison of Effect of Two Common First-line Triple Therapies on Helicobacter Pylori Infection

作　　者：斯锞[1] 廖文[1] 

机构地区：[1]成都市第一人民医院消化内科,四川成都610014

出　　处：《华西医学》2009年第4期896-898,共3页West China Medical Journal

摘　　要：目的:观察两种常用一线根除幽门螺杆菌(H.pylori)三联方案在本地区(成都市)的疗效。方法:纳入70例诊断为消化性溃疡、慢性糜烂性胃炎、慢性萎缩性胃炎伴H.pylori感染的患者。随机分为A、B两组。A组采用埃索美拉唑(E)20 mg bid+克拉霉素(C)500 mg bid+甲硝唑(M)400 mg bid,B组采用E 20 mg bid+C 500 mg bid+阿莫西林(A)1.0g bid治疗,疗程7天。H.pylori根除失败者以1周四联方案:E 20 mg bid+胶体次枸櫞酸铋(B)220 mg bid+呋喃唑酮100 mg bid+A1.0g bid治疗,观察疗效。结果:64例完成实验。三联方案H.pylori根除率:A组62.5%,B组84.4%,有显著差异(P<0.05)。二线四联方案根除率94.1%。结论:ECA方案H.pylori根除率明显高于ECM方案,可能更适合于本地区根除H.pylori的一线治疗,EBFA方案作为二线治疗具有较高疗效。Objective： To observe the effect of two common first-line triple therapy on H elicobacter pylori（H, pylori） Infection. Methods： Seventy patients diagnosed as peptic ulcer, chronic erosive gastritis and chronic atrophic gastritis with of H. pylori were included and randomly divided into two groups. A group was administered with esomeprazole（E） 20rag bid, clarithromycin（C） 500rag bid and metronidazole（M） 400rag bid,B group received E and C combined with amoxicillin（A）1. 0g bid. The treatment duration was 7 days. The patients with H. pylori unsuccessful eradication were administered with E 20mg bid, colloidal bismuth subcitrate（B） 220mg bid, Furanzolidone（F） 100mg hid and A 1.0g bid for 7days. Results：Sixty-four patients completed the study. The H. pylori eradication rates of triple therapy： A group was 62.5% ,B group was 84.4%. The difference was significant （P〈0.05）. The H. pylori eradication rate of the quadruple therapy was 94.1%. Conclusion： The H. pylori eradication rate of ECA triple therapy is significantly higher than the ECM regimen. It may be better to choose the former as the first-line therapy in Chengdu. The quadruple therapy EBFA is effective for the second-line of H. pylori eradication.

关 键 词：幽门螺杆菌 根除 三联 疗效 

分 类 号：R573[医药卫生—消化系统]