新型喜树碱缓释微胶囊的制备  

Fabrication of novel microcapsules for controlled release of camptothecin

作　　者：马艳[1] 岳秀丽[2] 马放[2] 王洋[3] 田文杰[4] 阎秀峰[3] 任南琪[2] 

机构地区：[1]哈尔滨工业大学生物医学工程研究中心纳米医药与生物传感器实验室,哈尔滨150080 [2]哈尔滨工业大学城市水资源与环境国家重点实验室,哈尔滨150090 [3]东北林业大学生命科学学院,哈尔滨150040 [4]大连民族学院生命科学学院,大连116600

出　　处：《哈尔滨工业大学学报》2009年第4期48-50,共3页Journal of Harbin Institute of Technology

基　　金：国家高技术研究发展计划资助项目(2007AA03Z316);教育部高等学校科技创新工程重大项目培育资金资助项目(707021);黑龙江省自然科学基金资助项目(C200605);哈尔滨市留学归国基金资助项目(2005AFLGJ004)

摘　　要：为了降低喜树碱药物的毒性,提高人体服药后的顺应性.以生物相容性良好的壳聚糖和海藻酸钠为囊壁材料,喜树碱药物微粒为囊芯,采用静电吸引层层纳米自组装技术(LbL法)制备了喜树碱微胶囊.实验结果表明:LbL法制备的微胶囊用激光共聚焦显微镜观察具有明显的核-壳结构;提高了喜树碱在水中的分散性;释放速度可控,不同包裹层数的微胶囊在模拟人体体液环境下(pH7.4)释放速度不同,随着高分子层数增加,药物释放速度降低.这种具有缓控释效果的微胶囊能大大降低病人服药后的不良反应,具有很好的应用前景.To lower down the toxicity of camptothecin （CPT）, microcapsules loadcd with CPT were prepared by using a novel coating technology based on the layer-by-layer （LbL） deposition of oppositely charged chitosan and alginate polyelectrolytes with good biocompatibility on to microcrystal templates Expermental results show that the microcapsules fabricated by this method have visible cove-shell structure observed by confocal laser scanning microscopy （CLSM）, rite dispersibility of CPT in water is enhanced, and the release rate can be controlled The release rate of CPT decreases as the increasing wall thickness （the number of polyelectrolyte layers deposited onto the microcrystal cores）. These microcapsules can reduce the side effects induced by CPT and possess great potential for future application

关 键 词：喜树碱 微胶囊 控制释放 层层自组装 

分 类 号：R94[医药卫生—药剂学]