盐酸异丙嗪的微波增敏方波伏安法测定  

Determination of Promethazine Hydrochloride by Square Wave Voltammetry in the Presence of Microwave Activation

作　　者：程龙军[1] 李利军[2] 程昊[2] 蔡卓[1] 钟亮[1] 

机构地区：[1]广西大学化学与化学工程学院,广西南宁530004 [2]广西工学院生物与化学工程系,广西柳州545006

出　　处：《分析测试学报》2009年第5期581-584,共4页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(20665001);广西科学基金资助项目(0640029)

摘　　要：以玻碳电极作工作电极,在微波作用下用循环伏安法和方波伏安法研究了盐酸异丙嗪的电化学特性,结果表明微波可以增大峰电流,并应用于盐酸异丙嗪的检测,建立了一种新的检测盐酸异丙嗪的电化学方法。在最佳实验条件下,无微波作用时用方波伏安法检测盐酸异丙嗪,其响应电流与盐酸异丙嗪的浓度在4.0×10-6～1.0×10-4mol/L范围呈线性关系(r=0.9982,n=7),线性回归方程为I(A)=0.0403c(mol/L)+5.0×10-7,检出限为4.0×10-7mol/L;在微波作用下用方波伏安法检测盐酸异丙嗪,其响应电流与盐酸异丙嗪的浓度在4.0×10-6～1.0×10-4mol/L范围有很好的线性关系(r=0.9991,n=7),线性回归方程为I(A)=0.0457c(mol/L)+6.0×10-7,检出限为2.0×10-7mol/L。在4.0×10-6～1.0×10-4mol/L范围微波增敏的峰电流与无微波条件下峰电流的比值平均值为1.22。该方法用于盐酸异丙嗪片的测定,结果满意。The electrochemical characteristics of promethazine hydrochloride were studied by cyclic voltammetry and square wave voltammetry under microwave radiation and a considerable current enhancement was observed for promethazine hydrochloride in 0.05 mol/L H2 SO4. Based on this, a new electrochemical method for the determination of promethazine hydrochloride was established. Under the optimal conditions, the square wave voltammetry showed a good linearity for 4. 0 ×10-6--1.0×10-4 mol/L promethazine hydrochloride in the absence of microwave activation with a detection limit of 4.0×10-7 mol/L and the linear regression equation was I（A） = 0. 040 3c（tool/L） ＋ 5.0 ×10- 7. While in the presence of microwave activation it exhibited a good linearity for 4. 0 ×10-6 - 1.0 ×10-4 mol/L promethazine hydrochloride with a detection limit of 2.0 ×10-7 mol/L and the line- ar regression equation was I（A） = 0. 045 7c（mol/L） ＋ 6.0 ×10-7. The average ratio of peak cur- rents with microwave activation to those without microwave activation was 1.22 in the rang of 4. 0×10-6 - 1.0 ×10-4 mol/L promethazine hydrochloride. The recoveries was 90%- 107% . The proposed meth- od was applied to the determination of promethazine hydrochloride tablet with satisfactory results.

关 键 词：微波 盐酸异丙嗪 方波伏安法 循环伏安法 

分 类 号：O657.1[理学—分析化学] R971.3[理学—化学]