MEGX试验对肝脏储备功能评估价值  

Evaluation of the liver reserveof rats with experimental livercirrhosis in hepatectomy by MEGX test

作　　者：李建华[1] 邬林泉[1] 刘石龙[1] 罗志强[1] 傅华群[1] 

机构地区：[1]南昌大学第二附属医院肝胆外科,江西省南昌市330006

出　　处：《世界华人消化杂志》2009年第11期1126-1129,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨单乙基甘胺酰二甲苯胺(MEGX)试验对肝脏储备功能评估的价值.方法:采用改良复合因素(CCl4、胆固醇、乙醇)制备大鼠肝硬化模型,将40只雄性肝硬化大鼠完全随机分成A、B、C、D组4组,每组10只,分别行不同肝切量的肝切除(0%、15%、30%、45%).术前、术后行MEGX试验、吲哚氰绿排泄(ICGR15)试验、常规肝功能检测,并对切除的肝组织进行常规病理检查.结果:实验组(B、C、D组)肝切后大鼠血清MEGX的量较肝切前均有不同程度的下降(30.22±10.6μg/Lvs37.52±14.01μg/L,22.68±6.19μg/Lvs38.47±15.24μg/L,12.60±5.88μg/Lvs37.26±13.87μg/L,均P<0.05).且随着肝切量的增加,MEGX的量明显减少,术后各组间比较均有显著性差异(P<0.05).结论:MEGX试验能较灵敏反映肝储备功能受损的程度,优于常规肝功能检测及ICGR15试验.AIM： To study the effectiveness of MEGX test in evaluating liver reserve of rats with experimental liver cirrhosis in different hepatectomy. METHODS： A rat model of liver cirrhosis was established with improved and complex factors （CCl4, cholesterol, alcohol）. Forty male SD cirrhosis rats were randomly divided into 4 groups; the rats of all groups underwent different partial hepatectomy （A group： 0%; B group： 15%; C group： 30%; D group： 45%）. MEGX, ICGR15 and common hepatic function were performed, and the liver tissue samples were taken for pathologic examination. RESULTS： MEGX were lower following partial hepatectomy in experimental groups （B, C, D groups） （30.22 ± 10.6 μg/L vs 37.52 ± 14.01 μg/L, 22.68 ± 6.19 μg/L vs 38.47 ± 15.24 μg/L, 12.60 ± 5.88 μg/L vs 37.26 ± 13.87 μg/L, all P 〈 0.05）. With the extracted liver tissue increased, the serum level of MEGX was decreased obviously. There were significant differences among all postoperative groups for MEGX concentrations （P 〈 0.05）. CONCLUSION： The MEGX test can sensitively reflect the damage to liver reserve capacity, which is better than ICGR15 test or conventional liver function tests.

关 键 词：MEGX试验 肝储备功能 肝切除 肝硬化 大鼠 模型 

分 类 号：R575[医药卫生—消化系统]