食管癌发生与人乳头状瘤病毒感染相关性的Meta分析  

Metaanalysis of relationship between tumorigenesis of esophageal carcinoma and human papillomavirus infection

作　　者：张东红[1] 朱毅[1] 沈忠英[2] 张庆英[3] 

机构地区：[1]汕头大学医学院心血管中心,广东省汕头市515041 [2]汕头大学医学院病理学教研室,广东省汕头市515041 [3]汕头大学医学院公共卫生教研室,广东省汕头市515041

出　　处：《世界华人消化杂志》2009年第11期1130-1134,共5页World Chinese Journal of Digestology

摘　　要：目的:综合评价人乳头状瘤病毒(human papillomavirus,HPV)感染与食管癌发生的相关性.方法:检索1987-01/2008-11国内外公开发表的有关我国人群食管癌和正常食管组织中HPV感染的文献报道.研究纳入标准是以聚合酶链反应和/或原位杂交法检测HPVDNA的食管癌病例-对照研究,对所得资料进行Meta分析.结果:共有15组病例-对照研究符合入选标准,累积食管癌患者1174例和正常对照人群988例.Meta分析显示,食管癌组织中HPV感染的合并优势比是正常食管组织的4.29倍(95%CI:2.38-7.70).食管癌组织和正常食管组织中HPV的平均感染率在高发区均显著高于低发区(59.26%vs34.66%,χ2=66.05,P<0.001;42.50%vs15.82%,χ2=66.02,P<0.001).结论:人乳头状瘤病毒感染可增加国人食管癌发生的危险性,尤其是在食管癌高发区.AIM： To synthetically evaluate the relationship between human papillomavirus （HPV） infection and the tumorigenesis of esophageal carcinoma.METHODS： Research articles about HPV infection and the development of esophageal carcinoma were collected from journals published from Jan 1987 to Nov 2008. The searching criteria included all randomized evidence for HPV DNA detection with polymerase chain reaction （PCR） or in situ hybridization （ISH）. Meta-analysis was performed to re-analyze those references synthetically. RESULTS： A total of 15 trials including 1174 esophageal carcinoma patients and 988 normal controls were collected. Meta-analysis revealed that the combined odds ratios （ORc） for HPV infection in esophageal carcinoma was 4.29 （95%CI： 2.38-7.70） times higher than that of normal esophagus mucosa. The mean positive rates for HPV infection in esophageal carcinoma and normal esophageal mucosa tissues were both significantly higher in areas with high prevalence than in areas with low prevalence （59.26% vs 34.66%, χ^2 = 66.05, P 〈 0. 001; 42.50% vs 15.82%, χ^2 = 66.02, P 〈 0. 001）. CONCLUSION： HPV infection increases the risk of tumorigenesis of esophageal carcinoma, especially in areas with high prevalence of esophageal carcinoma in China.

关 键 词：人乳头瘤状病毒 食管癌 META分析 

分 类 号：R735.1[医药卫生—肿瘤]