重型肝炎患者外周血干细胞因子水平及临床意义  

Serum levels of stem cell factor and their clinical signif icances in patients with severe hepatitis

作　　者：刘军英[1] 林世德[1] 苏毅[1] 龙骏[1] 黄晓刚[1] 

机构地区：[1]遵义医学院第一附属医院感染科,贵州省遵义市563003

出　　处：《世界华人消化杂志》2009年第12期1264-1268,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨重型肝炎患者外周血干细胞因子(stem cell factor,SCF)与其肝损害程度及预后的关系.方法:贵州省遵义医学院第一附属医院住院的肝炎患者45例及门诊体检者15例.肝炎患者分为急性肝炎组15例,慢性肝炎组16例和重型肝炎组14例;重型肝炎患者又分为好转组4例,死亡组10例.ELISA法检测各组血清SCF水平.结果:重型肝炎患者血清SCF水平明显高于急性肝炎、慢性肝炎和健康对照组,差异具有统计学意义(2403.1±42.8ng/Lvs2354.9±19.0ng/L,2376.7±16.4ng/L,2358.4±16.0ng/L,均P<0.05).重型肝炎患者死亡组血清SCF水平明显高于好转组,差异有统计学意义(2418.1±50.7ng/Lvs2376.3±11.7ng/L,P<0.05).血清SCF与肝细胞生长因子有明显正相关(r=0.38,P<0.01).SCF与血清白蛋白、凝血酶原时间活动度呈明显负相关(P<0.01).结论:重型肝炎患者外周血清SCF水平随着肝损害程度加重而明显升高,提示严重肝损害时,肝再生可能需要干细胞的参与.AIM： To investigate the serum levels of stem cell factor （SCF） and their clinical significances in patients with severe hepatitis. METHODS： A total of 45 hepatitis patients （including 15 cases of acute hepatitis, 16 cases of chronic hepatitis and 14 cases of severe hepatitis） and 15 healthy subjects （as controls） were collected from our hospital. The severe hepatitis patients were divided into survival subgroup （n = 4） and death subgroup （n = 10）. Serum levels of SCF were measured by enzyme-linked immunosorbent assay （ELISA）. RESULTS： The levels of serum SCF were significantly higher in severe hepatitis than those in acute hepatitis, chronic hepatitis and the controls （2403.1 ± 42.8 ng/L vs 2354.9 ±19.0 ng/L, 2376.7 ± 16.4 ng/L, 2358.4 ±16.0 ng/L; all P 〈 0.05）, and also higher in the death subgroup than those in the survival subgroup （2418.1 ±50.7 ng/L vs 2376.3 ± 11.7 ng/L, P 〈 0.05）. The levels of serum SCF showed significantly positive correlation （r = 0.38, P 〈 0.01） with those of hepatocyte growth factor （HGF） and significantly negative correlation with those of albumin and prothrombin time activity （PTA）. CONCLUSION： Serum levels of SCF may reflect the degree of hepatic injury and the prognosis of severe hepatitis patients, indicating that stem cells may be required for liver regeneration in severe hepatitis patients.

关 键 词：重型肝炎 干细胞因子 肝细胞生长因子 

分 类 号：R575.1[医药卫生—消化系统]