Bmi-1、Caspase-8蛋白在原发上皮性卵巢癌中的表达及其临床意义  

Expression and clinical significance of Bmi-1,Caspase-8 protein in primary epithelia ovarian cancer

作　　者：刘春华[1] 唐良萏[1] 汤为学[2] 

机构地区：[1]重庆医科大学附属第一医院妇产科,重庆400016 [2]重庆医科大学病理生理教研室,重庆400016

出　　处：《重庆医科大学学报》2009年第6期712-717,共6页Journal of Chongqing Medical University

摘　　要：目的:探讨Bmi-1、Caspase-8蛋白表达与卵巢癌发生、发展及复发的关系。方法:采用免疫组织化学SABC法,测定26例浆液性、22例粘液性、12例内膜样卵巢癌,16例良性卵巢肿瘤和10例正常卵巢组织中Bmi-1、Caspase-8蛋白表达情况。结果:Bmi-1蛋白在卵巢癌组中表达(68.3%)高于良性组(37.5%)和正常组(10.0%);Caspase-8蛋白在卵巢癌组中表达(31.7%)低于良性组(68.8%)和正常组(90.0%);Bmi-1、Caspase-8在卵巢癌组织中的表达呈负相关关系(r=0.296)。结论:Bmi-1、Caspase-8的蛋白作为一种新型肿瘤标志物,与卵巢癌发生、发展及复发密切相关。Objective：To study the relationship between Bmi-1, Caspase-8 protein expression and carcinogenesis,progression and recur-rence of ovarian cancer. Methods： A specific and sensitive immunohistochemical SABC assay was used to detect the expression of Bmi-1,Caspase-8 in paraffin-embedded sections of 60 cases of primary epithelia ovarian cancer, 16 cases of epithelial benign ovarian tumors,and 10 cases of normal ovarian tissues individual. Results： The positive expressions of Bmi-1 in epithelial ovarian cancers （68.3%） were significantly higher than those in normal tissues （ 37.5% ） and benign ovarian tumors （ 10.0% ） The positive expressions of Caspase-8 in epithelial ovarian cancers （31.7%） were significantly lower than those in normal tissues （68.8%） and benign ovarian tumors （90.0%）. It showed the tendency that the expression of Bmi- 1 increased and Caspase-8 decrease of the histological differentiation （P〈0.05） and progress of clinical stages（P〈0.05）. Conclusion： As a new tumor marker,the expression of Bmi-1 and Caspase-8 is obviously related to the carcinogenesis,progression,and recurrence of ovarian ca ncer.

关 键 词：BMI-1 CASPASE-8 卵巢癌 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]