NMR研究β-环糊精对布洛芬的手性识别  

NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes

作　　者：王恩举[1] 陈光英[1] 彭明生[1] 

机构地区：[1]海南省热带药用植物化学重点实验室 海南师范大学化学系,海南海口571158

出　　处：《波谱学杂志》2009年第2期216-222,共7页Chinese Journal of Magnetic Resonance

基　　金：海南师范大学博士科研启动资助项目(103303)

摘　　要：用1H NMR和13C NMR研究了β-环糊精对外消旋布洛芬的手性识别.外消旋布洛芬与β-环糊精形成包合物后,其1H NMR和13C NMR图谱的化学位移和峰形都有所变化,手性碳附近的某些原子所对应的吸收峰裂分为两组信号,这两组信号分别对应布洛芬的两种対映异构体.结果显示,对于布洛芬,β-环糊精是一个方便而有效的手性溶解剂.The chiral recognition of racemic ibuprofen by β-cyclodextrin was studied by ^1H- and ^13C NMR spectroscopy. The ^1 H and ^13C spectra of ibuprofen complexing with β-cyclodextrin were shown to be different from those of free ibuprofen. Some peaks of the atoms adjacent to the chiral carbon atom showed splitting into two parts, corresponding to the two enantiomers of ibuprofen respectively. The result demonstrated that β-cyclodextrin can be used as a convenient and effectual chiral solvating agent.

关 键 词：核磁共振(NMR) Β-环糊精 布洛芬 手性识别 手性溶解剂 

分 类 号：O657.2[理学—分析化学]