顶空气相色谱法测定盐酸氮卓斯汀中残留溶剂  

Determination of residual solvents in azelastine hydrochloride by head-space gas chromatography

作　　者：胡佰艳[1] 金松子[2] 蒋庆峰[2] 

机构地区：[1]河南大学药学院,开封475001 [2]天津药物研究院分析测试中心,天津300193

出　　处：《现代仪器》2009年第3期16-17,共2页Modern Instruments

摘　　要：建立毛细管气相色谱法测定盐酸氮卓斯汀中残留溶剂。采用DB-624毛细管色谱柱,FID检测器,二甲基甲酰胺为溶剂,程序升温,外标法同时检测盐酸氮卓斯汀中乙醇、丙酮、二氯甲烷、正己烷4种有机溶剂残留量。各待测组分完全分离,线性关系良好,检测限分别为3.51μg/mL、 0.35μg/mL、 2.12μg/mL、 0.11μg/mL,精密度RSD<5%,平均回收率99.1%-102.4%。本法操作简单,结果准确可靠,可用于盐酸氮卓斯汀中残留溶剂的检测。To establish a method for determining the four kinds of residual solvents in azelastine hydrochloride by headspace gas chromatography. The determination was carried out on a DB-624 capillary column（30mm×0.53mm, 3pro） with sequential increase of temperature programming. N,N-dimethyformamide as solvent media,with the FID detector .It appears a good linearity in the experimental concentration（r〉0.9991）. The detector limit of etha- nol, acetone, chloromethane and n-hexane separately were 3.51, 0.35,2.12,0.1 μg/mL. The RSD of precision were all less than5.0%. The average recoveries were 99.1%-102.4%. The method is simple, sensitive and accurate It could be used for detection of four residual solvents in azelastine hydrochloride.

关 键 词：盐酸氮卓斯汀 顶空气相色谱法 残留溶剂 

分 类 号：TQ111.3[化学工程—无机化工] TS227[轻工技术与工程—粮食、油脂及植物蛋白工程]