Mechanochemical Coupling of Kinesin Studied with a Neck-Linker Swing Model  

作　　者：LI Ming SHU Yao-Gen OU-YANG Zhong-Can 

机构地区：[1]College of Physical Science, Graduate University of Chinese Academy of Sciences, Beijing 100190, China [2]Key Laboratory of Frontiers in Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China

出　　处：《Communications in Theoretical Physics》2009年第6期1143-1148,共6页理论物理通讯（英文版）

基　　金：Supported by National Basic Research Program of China (973 Program) under Grant No. 2007CB935903

摘　　要：A neck-linker swing model has been proposed in this work to investigate the mechanochemical coupling of kinesin. The difference between force-velocity curves given by force clamp and fixed trap respectively has been satisfactorily interpreted by this model. The study implies that ADP releasing and ATP hydrolysis are much less forcedependent in force clamp experiments than that in fixed trap experiments in the regime of moderate loading force, which might be a consequence of the delayed response of servo system in force clamp experiments.

关 键 词：KINESIN neck-linker swing force clamp fixed trap 

分 类 号：TP273.2[自动化与计算机技术—检测技术与自动化装置] TV523[自动化与计算机技术—控制科学与工程]