Pregnane X receptor： a double-edged sword  

作　　者：FANG Dao-kui ZHANG Jian-qing 

机构地区：[1]Persistent Organic Pollutant Laboratory, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518020, China

出　　处：《Chinese Medical Journal》2009年第11期1333-1341,共9页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China （No. 30771778）.

摘　　要：During the last decade, much progress has been made in exploring the mechanisms of alterations elicited by foreign compounds in xeno- and endobiotic metabolism regulated by the human nuclear pregnane X receptor （PXR）. PXR, identified as a human nuclear receptor in 1998 and generally regarded as a sensor activated by exogenous and endogenous chemicals, regulates a large number of enzymes and transporters involved in the response of mammals to their chemical environment.During the last decade, much progress has been made in exploring the mechanisms of alterations elicited by foreign compounds in xeno- and endobiotic metabolism regulated by the human nuclear pregnane X receptor （PXR）. PXR, identified as a human nuclear receptor in 1998 and generally regarded as a sensor activated by exogenous and endogenous chemicals, regulates a large number of enzymes and transporters involved in the response of mammals to their chemical environment.

关 键 词：pregnane X receptor protein structure FUNCTION 

分 类 号：R969.6[医药卫生—药理学] R392.11[医药卫生—药学]