帕金森病相关生化标志物研究进展  

Research Progress of Biomarker of Parkinson’s Disease

作　　者：陆丽霞[1] 戚辰[1] 刘振国[1] 

机构地区：[1]上海交通大学医学院附属新华医院神经科

出　　处：《医学综述》2009年第11期1674-1676,共3页Medical Recapitulate

摘　　要：目前帕金森病（PD）的诊断仅依靠临床特征而缺乏相应的辅助检查方法。近年来,大量研究评估了影像学、药物试验、生化标志物及基因检测等对PD的诊断意义,其中外周体液标志物研究因其适用范围广,方便、创伤小、直接反应病理过程等特点得到重视。本文就α突触核蛋白、线粒体复合物Ⅰ和氧化应激以及多巴胺在该方面的相关研究予以综述。The diagnosis of Parkinson＇s disease （PD）only depend on clinical features and lack of supplementary examinations. A lot of researches assessed the imaging, treating test, biomarkers and genetic test on the diagnosis of PD. Peripheral biomarkers was got attention because of its wide scope of application, convenience, little trauma and its direct response to the pathological process of disease. This article reviewed the development of peripheral biomarkers, including α-synuclein, mithochondrial complex I, oxidative stress and dopamine.

关 键 词：帕金森病 生化标志物 Α突触核蛋白 线粒体复合物Ⅰ 氧化应激 

分 类 号：R742.5[医药卫生—神经病学与精神病学]