不同相对分子质量坛紫菜多糖抗疲劳作用的实验研究  

Anti-fatigue Effects of Polysaccharides with Different Relative Molecular Weight from Porphyra Haitanensis

作　　者：赵婷婷[1] 张全斌[2] 李智恩[2] 徐祖洪[2] 

机构地区：[1]中日友好医院临床研究所药物药理室,北京100029 [2]中国科学院海洋研究所海洋化学室,青岛266071

出　　处：《医药导报》2009年第6期709-712,共4页Herald of Medicine

基　　金：山东省优秀中青年科学家奖励基金资助项目(基金编号:2007BS07004)

摘　　要：目的研究不同相对分子质量的坛紫菜多糖(P1、P2、P3)和原料多糖(P)的抗疲劳作用。方法连续给药2周,观察不同相对分子质量坛紫菜多糖对小鼠爬杆时间的影响;对小鼠游泳时间的影响及小鼠肝糖原变化的影响。结果降解产物能提高体内肝糖原含量,且能显著延长小鼠的游泳和爬杆时间,这一作用随降解产物相对分子质量的降低而减弱,作用大小依次为P1>P2>P3。原料样品P能提高小鼠体内肝糖原含量,显著延长小鼠爬杆时间。结论降解产物能提高小鼠耐疲劳时间,促进肝糖原合成,发挥肝脏保护和促进体能恢复的作用,其功效强于原料P。Objective To investigate the anti-fatigue effects of polysaccharides with different relative molecular weight(P1,P2,P3) from Porphyra haitanensis and the natural one(P). Methods Mice were given with porphyrans for two weeks.The time of forced-swimming and pole climbing,and liver glycogens after forced-swimming test were detected. Results The degraded products increased liver glycogens,and significantly prolonged the time of forced-swimming and pole climbing in a molecular dependent manner as P1>P2>P3.The natural product P,elevated liver glycogen and prolonged the time of pole climbing as well. Conclusion The degraded porphyrans are more effective in anti-fatigue function and synthesis of glycogens than the natural one.

关 键 词：坛紫菜 多糖 抗疲劳 小鼠 

分 类 号：R282.71[医药卫生—中药学] R965[医药卫生—中医学]