驱虫斑鸠菊血清药物化学的初步研究  

Preliminary Study on Serum Pharmacochemistry of Traditional Uighur Medicine Vernonia Anthelmintica (L.) Willd

作　　者：刘晓东[1] 闫明 张兰兰[1] 霍仕霞[1] 

机构地区：[1]新疆维吾尔自治区石河子大学药学院,832003 [2]新疆维吾尔自治区维吾尔医药研究所,乌鲁木齐830049

出　　处：《医药导报》2009年第6期713-715,共3页Herald of Medicine

基　　金：国家科技支撑计划项目(基金编号:2007BAI30B012007BAI48B06)

摘　　要：目的对维药驱虫斑鸠菊进行血清药物化学研究,探讨驱虫斑鸠菊药效作用的物质基础。方法在建立驱虫斑鸠菊高效液相色谱(HPLC)指纹图谱的基础上,通过比较驱虫斑鸠菊水提取物、驱虫斑鸠菊含药血清和空白血清HPLC指纹图谱的差异,确定驱虫斑鸠菊血中移行成分。结果在驱虫斑鸠菊含药血清中发现了9种入血成分,其中5种为原型成分,其余4种可能为原型成分的代谢产物。结论9种入血成分可能是驱虫斑鸠菊的体内直接作用物质,对其进行深入研究将有助于阐明驱虫斑鸠菊的药效物质基础及药效机制。To explore the bioactive constituents of Vernonia anthelmintica （L.）Willd for its serum pharmacochemistry research. Methods The blood migrating constituents of Vernonia anthelmintica （L.）Willd were determined by comparing the HPLC fingerprints of the aqueous extracts, drug contained sera and blank sera. Results Nine compounds absorbed into blood were detected, five among which were original constituents of Vernonia anthelmintica（L. ）Willd, the rest might be metabolites of the original ones. Conclusion These nine constituents absorbed in blood could be bioactive components of Vernonia anthelmintica（L. ）Willd. Further studies on which would be useful to clarify the bioactive constituents and mechanisms of action of Vernonia anthelmintica（ L. ）Willd.

关 键 词：驱虫斑鸠菊 药物化学 代谢产物 色谱法 高效液相 指纹图谱 

分 类 号：R286[医药卫生—中药学] R969[医药卫生—中医学]