c-myc、P_(53)、Bcl-2和人类乳头状与涎腺肿瘤的关系  

The relationship among oncogene c-myc, tumour suppressor gene P_(53) and human papilloviruses in salivary gland tumours

作　　者：铁朝荣[1] 陈建钢[1] 范崇德[1] 李清[1] 李辉 

机构地区：[1]湖北医科大学附属第二医院,武汉430070

出　　处：《临床口腔医学杂志》1998年第2期70-72,共3页Journal of Clinical Stomatology

基　　金：湖北省教委资助

摘　　要：本文采用免疫组化、PCR技术，检测30例涎腺肿瘤组织中c－myc、P53、Bcl－2蛋白表达和HPV感染。结果显示：多形性腺瘤中，c－myc和P53阳性率分别为50．0％和25．0％，均低于恶性肿瘤阳性率的75．0％和50．8％，两组存在高度显著性差异（P＜0．01）；15例多形性腺瘤和3例鳞癌中，HPV6．11均为阴性，HPV16．18阳性反应各1例（1／15和1／3）。提示c－myc表达升高，与上皮细胞增殖速度加快及细胞癌变有关；P53蛋白表达，可为判断细胞分化程度的参考指标；HPV16．18具一定协同致癌作用。Bcl－2能引起细胞过度积聚，故为恶性肿瘤的发病机制之一。c-myc,P53 proteins and infections of HPV in salivary gland tumous were detected by immunohistochemical method and PCR. The results showed that in PA, the positive rates of c-myc and P53 were 50. 0% and 25. 0%. Both of them were lower than those of malignant tumours (75. 0% and 50. 8%). there were high defferances between two groups (P<0. 01 ). In 15 cases of PA and 3 cases of SCC, HPV6. 11 rections were all negative, but in 1 case of PA and 1 case of SCC, HPV16.18 staining were positive. The study indicates c-myc expressions were associated with cell proliferation and mutation, P53 overexpression can be a reference for cell differentiation. HPV16. 18 play a cooperation role in carcinogen. Because Bc1- 2 Could bring about cell accumulation, so it is one of mechanism for malignent tumour.

关 键 词：涎腺肿瘤 C-MYC 癌基因 抑癌基因 HPV 

分 类 号：R739.870.2[医药卫生—肿瘤]