247例中段食管癌不同处方剂量肺校正后生存率分析  

Adjustment of Radiation Dosage for Lung in the Radiotherapy of Middle Third of Esophageal Cancer

作　　者：师国珍[1] 李国文[1] 宋振中[1] 郭有中[1] 张海[1] 樊锐太[1] 邢本敬 

机构地区：[1]河南医科大学第一附属医院

出　　处：《中国肿瘤临床》1998年第5期332-333,共2页Chinese Journal of Clinical Oncology

摘　　要：目的：探讨中段食管癌放疗最佳剂量。方法：６０钴外照射中段食管癌２４７例，对处方量６５Ｇｙ组和７５Ｇｙ组拟行肺校正后靶区剂量分别为７２．５Ｇｙ和８５．５Ｇｙ。结果：肺校正后７２．５Ｇｙ组５年、８年、１０年、１３年生存率分别为１２．２％（１４／１１４）、７．９％（９／１１４）、５．２％（６／１１４）、１．８％（２／１１４）。８５．５Ｇｙ组５年、８年、１０年、１３年生存率分别为７．２％（９／１２５）、２．４％（３／１２５）、０．８％（１／１２５）、０（０／１２５）。两组对比７２．５Ｇｙ组明显高于８５．５Ｇｙ组（Ｐ＜０．００５）。结论：食管癌放疗行肺校正是必要的，校正后靶区剂量７２．５Ｇｙ左右，我们认为是根治性放疗最佳剂量。Purpose:Exploration of the best radiation dosage in the　radiotherapy　of the　middle third esophageal cancer by making adjustment for lung.Material and method: In the period of 1973 to 1976,247 cases of middle third esophageal cancer were treated with 60Co irradiation. The initial doses of 65Gy　group and 75Gy turned to 72.5Gy,85.5 Gy after the adjustment.Results: The 5, 8, 10, 13 year survival rates of the adjusted 72.5 Gy group were 12.2% (14/114), 7.9% (9/114), 5.2% (6/114), 1.8% (2/114), while those of the 85.5Gy group were 7.2% (9/125), 2.4% (3/125), 0.8% (1/125), 0% (0/125) respectively. In comparison, the survivals of the 72.5 Gy group were significantly higher than　those in the 85.5 Gy group (P<0.005). Conclusion: Lung adjustment is essential in radiotherapy of esophageal cancer and 72.5Gy is the optimal adjusted dosage.

关 键 词：食管癌 肺校正 剂量 放射疗法 靶区剂量 生存率 

分 类 号：R735.105[医药卫生—肿瘤] R730.55[医药卫生—临床医学]