nm23-H_1肿瘤转移抑制基因在肝细胞癌中的表达及其临床意义  

Expression of Human nm23H1Metastasis Suppressor Gene in Hepatocellular Carcinoma and Its Clinical Significance

作　　者：张松平[1,2,3] 倪灿荣[1,2,3] 戴益民 王能进[1,2,3] 

机构地区：[1]无锡市第四人民医院病理科 [2]第二军医大学病理学教研室 [3]江苏省启东肝癌研究所病理科

出　　处：《中国肿瘤临床》1998年第5期346-348,共3页Chinese Journal of Clinical Oncology

摘　　要：目的：研究ｎｍ２３－Ｈ１基因在肝癌中的表达。方法：应用免疫组化方法对１０４例肝细胞癌组织进行了ｎｍ２３－Ｈ１基因蛋白产物的检测，并结合术后随访资料分析了ｎｍ２３－Ｈ１的表达与患者预后的关系。结果：肝癌组织中ｎｍ２３－Ｈ１阳性产物主要表达在细胞浆内，阳性表达率为５１．９２％（５４／１０４）。ｎｍ２３－Ｈ１蛋白的表达与癌旁伴肝硬化病变以及肝细胞癌的侵袭生长和门静脉癌栓转移呈负相关。值得注意的是，ｎｍ２３－Ｈ１基因在肝癌切除术后无瘤生存期大于５～１０年以上病例中的阳性表达率高达８０％（２４／３０），而在术后１２～３２个月复发病例中的阳性表达率仅占２６．０９％（１２／４６）。结论：ｎｍ２３－Ｈ１低表达与癌肿复发密切相关，高表达是患者术后长期生存的一个重要因素。临床开展ｎｍ２３－Ｈ１基因的检测，对癌肿转移的早期诊断、确定合理治疗方案、提高治疗效果具有重要意义。The nm23H1 gene products/nucleoside diphosphate kinase(NDPK) expression in 104 cases of hepatocellular carcinoma tissues were determined by means of immunohistochemical method. The results showed that the positive rate of nm23H1 protein expression in hepatocellular carcinoma tissues was 51.92% (54/104). These immunoreactivities were most common in cytoplasm of tumor cells.The 　authors observed an inverse relationship between the expression of nm23H1 protein and the adjacent cirrhosis,invasiveness of hepatic cancer and intrahepatic　metastases. It was noted that the positive rate of nm23H1 protein expression in　HCC patients who had a long tumorfree survival time over 510 years was as high　as 80% (24/30), while the positive rate of expression in those who only had 　a　short survival time of 1232 months was as low as 26.09% (12/46).It suggests　that nm23H1 gene product may play an important role in suppressing the metastatic　phenotype.

关 键 词：肝肿瘤 肝细胞癌 NM23-H1 基因表达 预后 

分 类 号：R735.7[医药卫生—肿瘤]