PLGA-奥沙利铂缓释微球急性毒性实验  

Acute Toxicity Study of PLGA-Oxaliplatin Microsphere

作　　者：李井泉[1] 刘朝阳[2] 王世亮[3] 李荣[1] 

机构地区：[1]解放军总医院,北京100853 [2]中国医学科学院北京协和医学院肿瘤医院肿瘤研究所,北京1000212 [3]合肥工业大学控释药物研究室,合肥230009

出　　处：《中国比较医学杂志》2009年第5期50-52,共3页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(30371390)

摘　　要：目的了解PLGA-奥沙利铂缓释微球和奥沙利铂小鼠皮下给药的急性毒性。方法采用Bliss法分别测定PLGA-奥沙利铂缓释微球和奥沙利铂小鼠皮下给药对动物的半数致死量(LD50)。结果PLGA-奥沙利铂缓释微球小鼠皮下给药时的LD50为660.90 mg/kg,奥沙利铂小鼠皮下给药时的LD50为15.24 mg/kg,相差达43.37倍。结论PLGA-奥沙利铂缓释微球能够显著降低药物对动物的急性毒性。Objective To study the acute toxicity of slow-release PLGA （Poly lactic-co-glycolic Acid）-Oxaliplatin microsphere and Oxaliplatin through same injection route on mice. Method PLGA-Oxaliplatin microsphere and Oxaliplatin was injected subcutaneously on mice, Bliss procedure was used to determine the LD50 . Results The LD50 of PLGA-Oxaliplatin microsphere on mice was 660.90 mg/kg, Oxaliplatin was 15.24 mg/kg. Conclusion PLGA-Oxaliplatin microsphere can markedly reduce the acute toxicity of Oxaliplatin on mice.

关 键 词：奥沙利铂 缓释 微球 急性毒性 半数致死量 

分 类 号：R735.37[医药卫生—肿瘤]