多肿瘤标志物蛋白芯片检测在乳腺癌早期诊断中的价值  

Diagnostic value of multi-tumor markers protein biochip detection system in breast cancer

作　　者：汪覆鸣[1] 冷丽佳[1] 李晓军[2] 

机构地区：[1]长安大学医院,陕西西安710064 [2]西安交通大学医学院第一附属医院,陕西西安710061

出　　处：《现代肿瘤医学》2009年第6期1094-1096,共3页Journal of Modern Oncology

摘　　要：目的:研究多肿瘤标志物蛋白芯片(C12)联合检测在乳腺癌早期诊断中的价值。方法:对病理确诊的200例乳腺恶性肿瘤妇女进行12种肿瘤标志物的联合定量检测,采用100例女性健康献血员作为对照。对检查结果的漏诊率、误诊率、灵敏度和特异度等指标进行分析。结果:200例早期乳腺癌患者有106例血清肿瘤标志物为阳性,阳性率为53%;100名健康妇女有12例肿瘤标志物为阳性,假阳性率(误诊率)为12%。肿瘤标志物蛋白芯片对乳腺癌的定性诊断的灵敏度为53%,特异度为88%。结论:多肿瘤标志物蛋白芯片用于乳腺癌辅助诊断具有一定参考价值,但误诊率和漏诊率都比较高,有待进一步改善。Objective：To study the diagnostic value of 12 kinds of tumor markers in protein biochip detection system （C12 detection system for short）. Methods： C12 was used to quantitatively detect 12 kinds of tumor markers （ CEA, AFP, CA125, CA19 - 9, NSE, CA242, HCG, HGH, CA15 - 3, F - PSA, PSA, Ferritin） in the sera of 200 patients with primary breast cancer and 100 healthy women. Results： Of the 22 early - staged breast cancer patients, 106 （53%） presented positive tumor marker. Of the 100 healthy women, positive tumor marker was detected in 12 （12%）, demonstrating that the sensitivity and specificity for diagnosis of breast cancer were 53 % and 88%, respectively,with tumor marker protein biochip. Conclusion： To early breast cancer, the diagnostic value of multi - tumor markers protein biochip detection system （C12 detection system） is limited,it can only be used to enhance the efficiency and accuracy of the tumor detection in clinic.

关 键 词：乳腺癌 诊断 多肿瘤标志物 蛋白芯片 

分 类 号：R737.9[医药卫生—肿瘤]