肾透明细胞癌中Ang-2的表达及与血管生成的关系  

Expression of angiopoietin-2 in clear cell renal carcinoma and relation to tumor angiogenesis

作　　者：蔡大伟[1] 潘春雨[1] 卜仁戈[1] 詹运洪[1] 陈小楠[1] 王科峰[1] 吴斌[1] 

机构地区：[1]中国医科大学附属盛京医院第一泌尿外科,沈阳110004

出　　处：《现代肿瘤医学》2009年第6期1107-1109,共3页Journal of Modern Oncology

摘　　要：目的:探讨Ang-2及CD34在肾透明细胞癌中的表达及与肾透明细胞癌血管生成的关系。方法:应用免疫组化S-P法,分别检测80例肾透明细胞癌组织及10例癌旁肾组织中Ang-2及CD34的表达。结果:肾透明细胞癌组织中Ang-2阳性表达率为61.25%(49/80),明显高于癌旁肾组织。Ang-2的表达与肾透明细胞癌患者血尿、临床分期及淋巴结转移显著相关。结论:Ang-2可能在肾透明细胞癌血管生成中起重要作用,与肾透明细胞癌的分期、转移相关。Objective：To investigate the expression of angiopoietin -2 （Ang -2） and CD34 in clear cell renal carcinoma（ccRCC）, to evaluate the roles of Ang- 2, expression in tumor angiogenesis of clear cell renal carcinoma.Methods：The expression of Ang -2 and CD34 were measured by immunohistochemistry in tissue sections from 80 ccRCC and 10 cases of normal nephridial specimens. Results： The positive rate for expression of Ang- 2 in ccRCC was 61.25% （49/80） ,which was higher than that in normal nephridial tissue. The expression of Ang -2 revealed an positive correlation to tumorg clinical stage and metastasis. Conclusion：Ang -2 has relationship to ccRCC＇s anglogenesis,clinical stage and metastasis.

关 键 词：肾透明细胞癌 促血管生成素 肿瘤血管生成 

分 类 号：R737.1[医药卫生—肿瘤]