奥沙利铂、5-FU/LV治疗老年晚期胃肠道腺癌  

Oxaliplatin in combination with 5-FU/LV in elder patients with advanced gastrointestinal adenocarcinomas

作　　者：俎云芬[1] 李新[1] 罗雁[1] 刘馨[2] 

机构地区：[1]云南省第二人民医院肿瘤科,云南昆明650021 [2]云南省肿瘤医院肿瘤研究所,云南昆明650118

出　　处：《现代肿瘤医学》2009年第6期1132-1134,共3页Journal of Modern Oncology

摘　　要：目的:探索奥沙利铂/5-氟脲嘧啶/醛氢叶酸组成的方案在治疗老年进展期胃肠腺癌中的疗效和不良反应。方法:43例老年晚期胃肠腺癌患者(男性20例,女性23例,年龄70-79岁,胃腺癌15例、结直肠腺癌28例),采用奥沙利铂(oxaliplatin,L-OHP)85mg/m2d1,醛氢叶酸(leucovorin,LV)200mg/m2d1-5和5-氟脲嘧啶(5-florouracil5-FU)375mg/m2d1-5(即FOLFOX方案)联合化疗。每治疗1周,休息2周,3周为1周期,至少治疗2周期。评价疗效和不良反应。结果:可评价患者43人,其中完全缓解(CR)2例(4.7%),部分缓解(PR)13例(30.2%),稳定(SD)19例(44.2%),进展(PD)9例(20.9%)。总有效率34.9%。中位缓解期8.2月,中位生存期11月,1年生存率28.2%。不良反应主要为恶心,呕吐和骨髓抑制,多为Ⅰ-Ⅱ度;30.2%外周感觉神经异常均为Ⅰ度。结论:FOLFOX方案治疗老年进展胃肠腺癌疗效肯定,不良反应可耐受。Objective：To evaluate the efficacy and toxicity of combination chemotherapy with oxaliplatin （L - OHP ）, leucovorin （ LV ） and 5 - fluorouracil （ 5 - FU ） （FOLFOX） for elder patients with advanced gastrointestinal adenocarcinomas. Methods ： Forty three elder patients with advanced gastrointestinal adenocarcinomas （ male 20, female 23 ,age range 70- 79, gastric adenocarcinomas 15 and colorectal adenocarcinomas 28 ） received the combination chemotherapy ：L - OHP 85rag/m2 2 - hour infusion on dayl ,LV 200mg/m2/d d1-5 and 5 - FU 375mg,/m2/d d1-5 2 - hour infusions, repeated every 3 weeks as one cycle for at least 2 cycles. Responses to treatment and toxicity were recorded according to the WHO criteria and UICC toxicity criteria. Results：All patients were assessable for toxicity and response. Of 43 patients ,2 （4.7%） achieved complete responses （ CR）, 13 （ 30.2% ） achieved partial remissions （PR）, 19 （44.2%） achieved stable diseases （SD） , and 9 （20.9%） achieved progressive （PD）. All patients had a total response rate of 34.9% （ 15/43 ）. The median time of tumor remission and the median overall survival time were 8.2 months and 11 months, respectively. The survival rate of one year was 28.2%. The main toxicity included nausea/vomiting, myelosuppression and most toxicities were grade Ⅰ-Ⅱ. Peripheral neurosensory toxicity was observed in 30.2% （13/43） and just reached grade Ⅰ. Conclusion： FOLFOX appears to be effective and well -tolerable in eider patients with advanced gastrointestinal adenoearcinomas.

关 键 词：晚期胃肠腺癌 奥沙利铂 醛氢叶酸 氟尿嘧啶 

分 类 号：R735[医药卫生—肿瘤]