P-糖蛋白与口腔颌面部鳞癌多药耐药性关系的研究  

The correlation between P-glycoprotein and multidrug resistance of squamous carcinoma in oral and maxillofacial region

作　　者：谢志坚[1] 谷志远[1] 吴求亮[1] 孟海涛[2] 胡济安[3] 李松英[3] 

机构地区：[1]浙江医科大学附属第一医院口腔科 [2]浙江医科大学附属第一医院血液研究所 [3]浙江医科大学附属第一医院口腔病理教研室

出　　处：《中华口腔医学杂志》1998年第3期137-139,共3页Chinese Journal of Stomatology

基　　金：浙江省卫生厅科研基金资助

摘　　要：目的探讨口腔颌面部鳞癌对化疗药物耐药的机制。方法采用单克隆抗体ＭＲＫ１６，检测了４０例口腔颌面部鳞癌标本中的多药耐药基因产物Ｐ糖蛋白。结果鳞癌中Ｐ糖蛋白表达率为６２５％，有化疗史组的Ｐ糖蛋白水平显著高于未化疗组（Ｐ＜００５），分化较高组Ｐ糖蛋白水平显著高于分化较低组（Ｐ＜００５）。将Ｐ糖蛋白表达与临床化疗疗效对照，Ｐ糖蛋白预测化疗疗效的准确率为７５％。? Objective To study the mechanism of drug resistance of oral carcinoma to chemotherapy.Methods 40 cases of squamous carcinoma in the oral and maxillofacial region were examined for the multidrug resistance gene product Pglycoprotein using a monoclonal antibody MRK16.Results Pglycoprotein was detected in 62.5% of the sample. Pglycoprotein expression was related to the chemotherapy and the degree of differentiation. Pglycoprotein expression was higher in postchemotherapy group than in unchemotherapy group (P<0.05). Well differentiated tumors expressed Pglycoprotein more frequently (P<0.05). Pglycoprotein expression was compared with clinic response to chemotherapy. The accuracy rate of prediction is 75%.Conclusion Pglycoprotein plays an important role in mechanism of multidrug resistance of squamous carcinoma in the oral and maxillofacial region.【

关 键 词：抗药性 多药 癌 鳞状细胞 P糖蛋白 

分 类 号：R739.805[医药卫生—肿瘤]