不同种类乙型肝炎基因重组疫苗接种小学生2年抗体反应效果观察  

A clinical efficacy trial of different kinds of recombinant hepatits B vaccines;Chinese Hamster Ovary cell HB vaccine and Yeast HB vaccine

作　　者：梁争论[1,2,3] 李成明[1,2,3] 荆庆 向真[1,2,3] 杨超美 任玲君 张华远[1,2,3] 李河民 

机构地区：[1]中国药品生物制品检定所 [2]开封市卫生防疫站 [3]四川省卫生防疫站

出　　处：《中国公共卫生》1998年第6期323-324,共2页Chinese Journal of Public Health

基　　金：国家"九五"攻关基金

摘　　要：应用４批国产ＣＨＯ乙肝疫苗和２批进口酵母乙肝疫苗（Ｍｅｒｃｋ，Ａｍｇｅｎ），对３７０名小学生进行了２年（Ｔ２４）免疫效果观察。完成首针免疫后３月、（Ｔ３）７月、（Ｔ７）和１２月（Ｔ１２）时，各疫苗组的抗体阳转率均达９０％以上，其后开始下降。Ｔ７时国产ＣＨＯ疫苗抗体滴度与进口酵母疫苗无明显差异。Ｔ１２时Ａｍｇｅｎ疫苗组抗体ＧＭＴ显著高于其他各疫苗组。Ｔ２４时Ｍｅｒｃｋ苗组和一批ＣＨＯ苗组抗体滴度显著低于其他各疫苗组。结果表明国产ＣＨＯ疫苗抗体反应达到进口酵母疫苗水平。4 batches of Chinese Hamester Overy cell(CHO) derived vaccine(Institute of Changchun Biological Products,10ug/dose)and 2 batches of yeast derived vaccind(YDV:Amgen,10ug/dose,Merck,5ug/dose)were anministered to 370 children by 0,1,6 schedule.After vaccination(T7,T12),the antibody positive tates of all groups were above 90% and declined slowly afterwards.At the twelfth month from the first dose,the anti HBs level of Amgen group was significantly higher than these of other vaccines groups.However,The levels of Merck and CHO A group were significantly lower than that of other vaccines groups at T24.The results showed that the anti HBs response of CHO vaccine was similar to that of yeast vaccine.

关 键 词：乙型肝炎 基因重组疫苗 GMT 抗体反应 

分 类 号：R512.620.3[医药卫生—内科学]