吸烟、饮酒与食管癌死亡关系的前瞻性定群研究  

Prospective Cohort Study of Smoking and Drinking Associated with Death of Esophagus Cancer

作　　者：张世伟 马柯[1,2] 张爱华[1,2] 

机构地区：[1]山东省邹城市卫生局 [2]山东省邹城市卫生防疫站

出　　处：《中国公共卫生》1998年第6期327-329,共3页Chinese Journal of Public Health

摘　　要：于１９８２年６月对３个乡镇２９个村的２０岁以上男女村民１５８０３人前瞻性定群观察吸烟、饮酒与死亡的动态情况。结果表明，吸烟者食管癌死亡率１１４．８７／１０万人年，不吸烟者５２．９１／１０万人年，ＲＲ为２．１７，９５％ＣＩ为１．５３～３．０７（χ２＝２０．１１，Ｐ＝０．０００００７３），ＡＲ＝６１．９６／１０万人年，ＡＲ％＝５３．９４％。每日吸烟量与食管癌死亡之间存在明显的剂量－效应关系（Ｐ＜０．００１）。食管癌的死亡率，饮酒者为１０３．６３／１０万人年，不饮酒者为６７．２５／１０万人年，ＲＲ为１．５３，９５％ＣＩ为１．０８～２．１６（χ２＝５．９４，Ｐ＝０．０１４８）。食管癌死亡率随饮酒年限增加而升高（Ｐ＜０．００１），但与饮酒量不呈剂量－效应关系（Ｐ＞０．０５），单纯饮酒而不吸烟也未发现与食管癌有关。In order to investigate the association between the death of esophagus cancer(DEC) and smoking and drinking,a 12 5 year prospective cohort study was carried out in the rural area of Zoucheng City.In June 1982,29 villages from 3 townships were randomly sampled and 15803 male and female adult villagers(aged 20 years or more) were studied.Smoking and drinking status was recorded and the data concerning their death were collected every year.The results were as follows,DEC of smokers of both sexes was 114 87/100000 person year(PY)while it was 52 19/100000 PY for those non smokers.RR was 2 17,95%CI was 1 53 3 07(χ 2=20 11 P=0 0000073).AR was 61 96/100000 PY.AR% was 53 94%.Significant difference of dose response relation was observed between the smoking duration and the DEC.(P<0 001).The DEC of drinkers was 103 62/100000 PY while for those non drinker it was 67,25/100000 PY.RR was 1 53 and 95%CI was 1 08 2 16(χ 2=5 94,P=0 0148). The difference was significant.DEC was rising in accordance with prolonged drinking druaiton(P<0 001),but no significant difference of dose response relation was found between DEC and the drinking amount.

关 键 词：食管肿瘤 死亡 吸烟 饮酒 定群研究 

分 类 号：R735.1[医药卫生—肿瘤]