(3R,4R)-3-[(1′R)-叔丁基二甲基硅氧乙基]-4-乙酰氧基-2-氮杂环丁酮的合成  

Synthesis of (3R,4R)-4-Acetoxy-3-[(1'R-tert-butyl-dimethylsilyloxy)-ethyl]-2-azetidinone

作　　者：宋伟国 夏艳 高东升 宋成刚 

机构地区：[1]山东寿光富康制药有限公司,山东寿光262700

出　　处：《山东化工》2009年第5期16-19,共4页Shandong Chemical Industry

摘　　要：以化合物(3S,4S)-3-[(1′R)-叔丁基二甲基硅氧乙基]-4-羧基-1-对甲氧基苯基-2-氮杂环丁酮为主要原料,以卟啉锰为催化剂,经氧化脱羧,再由O3氧化脱保护基制得(3R,4R)-3-[(1′R)-叔丁基二甲基硅氧乙基]-4-乙酰氧基-2-氮杂环丁酮(4AA),两步反应总收率达到83.7%。采用卟啉锰做催化剂进行脱羧氧化反应,使该步反应收率达到了93.0%。用FT-IR、1HNMR对最终产物结构进行了表征。（ 3R, 4R ） - 4 - acetoxy - 3 - [ （ 1＇ R - tert - butyl - dimethylsilyloxy ） - ethyl ] - 2 - azetidinone （4AA） was prepared from （3S,4S） - 4 - carboxyl - 3 - [（I＇R - tert - butyl - dimethylsilyloxy） - ethyl] - 1 - p - methoxyphenyl - 2 - azetidinone through two - step process, involving the decarboxylation oxidation reaction which was catalyzed by manganese porphyrin and oxidized, and the reaction of oxidation using 03. The total yield of the reaction reached 83.7%. The use of manganese porphyrin catalyst raised the yield of this step to 93.0%. The product was characterized by means of FT - IR and l HNMR.

关 键 词：4AA 氮杂环丁酮 卟啉锰 培南 

分 类 号：TQ25[化学工程—有机化工]