VEGF基因多态性与汉族人银屑病易感性相关性研究  

Study on association between polymorphism of VEGF gene and psoriasis susceptibility in Chinese Han population

作　　者：路顺[1,2,3,4] 唐先发[1,2,3,4] 权晟[1,2,3,4] 周伏圣[3] 郑厚峰[1,2,3,4] 孙良丹[1,2,3,4] 崔勇[1,2,3,4] 肖风丽[1,2,3,4] 刘建军[2,3] 杨森[1,2,3,4] 张学军[1,2,3,4] 

机构地区：[1]安徽医科大学第一附属医院皮肤性病科,合肥230022 [2]安徽医科大学皮肤病研究所,合肥230032 [3]教育部重要遗传病基因资源利用重点实验室(省部共建),合肥230032 [4]安徽医科大学皮肤性病学系,合肥230032

出　　处：《安徽医科大学学报》2009年第3期318-321,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽医科大学国家重点实验室培育计划(编号:GJSYS-0801)

摘　　要：目的研究血管内皮生长因子(VEGF)基因单核苷酸多态性(SNP)与汉族人银屑病易感性的相关性。方法结合本课题组银屑病全基因组关联分析数据,在1103例银屑病患者和1104例正常对照中,应用Sequenom Mass Array质谱阵列技术对VEGF基因的SNP点rs2010963和rs9367178进行基因分型,用Plink1.03软件对数据资料进行统计分析。结果rs2010963(P=0.155)和rs9367178(P=0.65)位点等位基因频率在病例组和正常对照组之间的差异无统计学意义。对病例进行分层后分别与正常对照相比较,rs2010963和rs9367178的等位基因频率分布差异亦无统计学意义(P>0.05)。结论VEGF基因SNP点rs2010963和rs9367178可能与汉族人银屑病易感性不相关。Objective To investigate the association between single nucleotide polymorphism （SNP） in vascular endothelial growth factor （VEGF） gene and psoriasis susceptibility in Chinese Han population. Methods Based on the results of genome wide association study of psoriasis which were performed by our team, we used the Sequenom MassArray system to genotyped two single nucleotide polymorphism （rs2010963, rs9363178） of VEGF gene in 1 103 psoriasis cases and 1 104 normal controls, then we used the Plink 1.03 software for statistical analysis. Resuits There were no significant differences in allele frequencies for SNP rs2010963 （P =0.155 ）or rs9367178 （P = 0. 65）when compared all psoriasis patients with controls. And there were no significant differences in allele frequencies for SNP rs2010963 or rs9367178 when compared each subset with controls （P 〉 0. 05 ）. Conclusion It suggests that SNPs rs2010963 and rs9367178 of VEGF gene couldn＇t be related with psoriasis susceptibility in Chinese Han population.

关 键 词：银屑病/遗传学 血管内皮生长因子类/遗传学 多态性 单核苷酸 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R342.43[医药卫生—临床医学]