α-环戊基扁桃酸甲酯的合成  

Synthesis of Methyl Cyclopentylphenylglycolate

作　　者：于飞[1] 黄立鑫 李承铎[1] 王钝[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016 [2]东北制药总厂,辽宁沈阳110026

出　　处：《合成化学》2009年第3期385-387,共3页Chinese Journal of Synthetic Chemistry

摘　　要：苯乙酮酸与环戊二烯基溴化镁发生格氏反应,再经Pd/C催化氢化、甲酯化反应合成了α-环戊基扁桃酸甲酯,总收率23.4%,其结果经1H NMR表征。Methyl cyclopentylphenylglycolate was synthesized by reaction of benzoylformic acid with cyclopentadienyl Grignard reagent, and then by hydrogenation and estrification reaction. The total yield was 23.4%. The structure was characeterized by ^1 H NMR.

关 键 词：α-环戊基扁桃酸甲酯 苯乙酮酸 环戊二烯 合成 

分 类 号：R914.5[医药卫生—药物化学] O622.32[医药卫生—药学]