MnCl2催化交叉偶联合成沙坦联苯的工艺改进  

Process Improvenment on the Synthesis of Sartanbiphenyl by Cross-coupling Reaction Using MnCl_2 as a Catalyst

作　　者：张卫军[1] 吴运东[2] 刘西洋[2] 李治章[1] 向建南[2] 

机构地区：[1]湖南科技学院,湖南永州425100 [2]湖南大学化学化工学院,湖南长沙410082

出　　处：《合成化学》2009年第3期388-389,共2页Chinese Journal of Synthetic Chemistry

基　　金：湖南省自然科学基金重点资助项目(07JJ3019);湖南省科技厅基础研究支持项目(2007FJ3093);湖南省永州市科技局重点资助项目(200610);湖南大学化学传感与生物计量学国家重点实验室资助项目(200520)

摘　　要：以对氯甲苯为原料,THF为溶剂,经Grinard反应制得对甲苯基氯化镁格氏试剂,在MnCl2催化下格氏试剂与邻氯苯腈发生交叉偶联反应制得沙坦联苯,总收率80%,纯度大于99%。Sartanbiphenyl was synthesized using MnCl2 as a catalyst by the cross coupling reaction of o-chlorobenzonitrile with p-MeC6H4MgCl, which was prepared from p-chlorotoluene in THF by a Grinard reaction. The total yield was 80% with purity over 99%.

关 键 词：沙坦联苯 交叉偶合反应 MnCl2 工艺改进 

分 类 号：R914.5[医药卫生—药物化学] O625.2[医药卫生—药学]