间断口服铁剂改善儿童贫血及铁储备状态的研究  

Efficacy of orally intermittent iron supplementation on anemia and iron storage status in children

作　　者：赵丽娟[1] 郭小芳[1] 

机构地区：[1]江门市新会区妇幼保健院儿科,广东江门529100

出　　处：《中国儿童保健杂志》2009年第3期287-289,共3页Chinese Journal of Child Health Care

摘　　要：【目的】探讨不同口服铁剂补充方式改善儿童贫血及铁储备状态的作用。【方法】共107名营养性缺铁性贫血患儿随机分为常规量每日口服铁剂治疗组(A组),两日间隔口服铁剂治疗组(B组)以及每周间隔口服铁剂治疗组(C组)。测定三组患儿治疗前后血红蛋白(hemoglobing,HB)、红细胞平均容积(mean corpuscular volume,MCV)、红细胞平均血红蛋白量(mean corpuscular hemoglobin,MCH)和红细胞平均血红蛋白浓度(mean corpuscular hemoglobinconcentration,MCHC)、血清铁蛋白(serumferritin,SF)、可溶性转铁蛋白受体(soluble transferrin receptor,sTfR)水平及TfR-F指数。【结果】治疗后各组HB、MCV、MCH、MCHC以及SF均显著升高(P<0.05)而sTfR和TfR-F指数则明显降低(P<0.05),但组间无差异(P>0.05)。贫血改善率也无组间差异(P>0.05),但B组和C组的副反应发生率显著低于A组(P<0.05)。【结论】间断口服铁剂治疗缺铁性贫血副作用小,服药次数少,有利于贫血的恢复和改善铁营养状况。[Objective] To estimate the effect of different orally intermittent iron supplementation on anemia of children. [Methods] A total of 107 iron deficient children were randomized into three groups： daily iron supplementation group （group A）, twice weekly iron supplementation group （group B） and weekly iron supplementation group （group C）. The levels of hemoglobin （HB）, mean corpuscular volume （MCV）, mean corpuscular hemoglobin （MCH） and mean corpuscular hemoglobin concentration （MCHC）, serum ferritin （SF）, soluble transferin receptor, sTfR） and TfR-F index before and after treatment were measured. [Results] HB, MCV, MCH, MCHC and SF significantly increased （P〈0. 05） while sTfR and TfR-F index decreased significantly （P〈0.05） in each group after supplementation. No different changes of these indicators and the prevalence of anemia was found among the groups （P〉0.05）. But the incidence of side reaction in group B and C was significantly lower than that in group A （P〈0.05）. [Conclusion] Orally intermittent iron supplementation with curative efficiency and safety, was an appropriate iron supplementary mode to children.

关 键 词：缺铁性贫血 间断口服治疗 儿童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]