基于简单铜盐催化氮宾反应的意外产物的合成  

Study on unexpected product based on the catalyged nitrene reaction by simple copper salt

作　　者：罗新峰[1] 黄文才[2] 尹海滨 郑虎[1] 邓津津 何菱[1] 

机构地区：[1]四川大学华西药学院靶向药物中国教育部重点实验室,四川成都610041 [2]四川大学化工学院,四川成都610041 [3]广州市元通医药技术有限公司,广东广州510630

出　　处：《华西药学杂志》2009年第3期224-226,共3页West China Journal of Pharmaceutical Sciences

基　　金：广东省教育部产学研结合项目资助(2007B090400016)

摘　　要：目的合成一系列乙撑亚胺类具有生物活性的化合物。方法微波辅助氮宾烷化反应。结果意外得到系列缩短了碳链的化合物。结论所用方法能缩短反应时间,并可得到缩短碳链的产物。OBJECTIVE To synthesize a series of ethylene imine type of biologically active compounds. METHODS Reaction of nitrene was synthesized by Microwave - assisted. RESULTS A series of compounds with the carbon chain reduced were synthesized. CONCLUSION The method can not only simplify the reaction process, but also get the compounds of which the carbon chain were reduced.

关 键 词：乙撑亚胺 氮宾 微波辅助 抗肿瘤药 

分 类 号：R914[医药卫生—药物化学]