^99Tc^m-二亚乙基三胺五乙酸与^99Tc^m-奥曲肽眼眶显像在甲状腺相关性眼病中的对比研究  

A comparative study of ^99Tc^m-diethylene triaminepentaacetic acid and ^99Tc^m-octreotide orbital scan in thyroid associated ophthalmopathy

作　　者：杨宝军[1] 李险峰[1] 陆克义[1] 赵德善[1] 李思进[1] 

机构地区：[1]山西医科大学第一医院核医学科,太原030001

出　　处：《国际放射医学核医学杂志》2009年第1期22-25,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的通过对比^99Tc^m-二亚乙基三胺五乙酸（^99Tc^m-DTPA）与^99Tc^m-奥曲肽（^99Tc^m-OCT）眼眶显像，比较两种显像方法在评估甲状腺相关眼病（TAO）患者眼部炎性反应活动度中的临床价值。方法26例TAO患者依据临床活动度评分（CAS）标准分为炎性反应活动组16例、非炎性活动组10例，另有14名正常志愿者作为对照组。静脉注射^99Tc^m-DTPA 740 MBq，0．5h后行眼眶平面及体层显像，隔日同一患者静脉注射^99Tc^m-OCT740MBq，1-2h后行眼眶平面及体层显像。获取各组两种眼眶显像剂的摄取率。对两种显像方法获得的半定量指标UROCT和URDTPA进行配对t检验并分别与CAS评分进行Spearman相关性分析。结果两种显像剂的眼眶摄取率未见明显差异（t=0．075，P〉0．05）。两种显像剂的眼眶摄取率（UROCT、URDTPA）与患者CAS评分之间具有很好的相关性（^99Tc^m-DTPA：r=0．835，P〈0．001；^99Tc^m-OCT：r=0．912，P〈0．001）。结论^99Tc^m-DTPA与^99Tc^m-OCT的眼眶显像有较好的一致性，证明^99Tc^m-DTPA眼眶显像是一种可行的、并可能成为一种很有发展前景的评价TAO炎性反应活动度的新方法。Objective Through a comparative study of ^99Tc^m-diethylenetriaminepentaacetic acid （^99Tc^m-DTPA） and ^99Tc^m-octreotide （^99Tc^m-OCT） SPECT orbital scan, evaluated the clinic significance of two imaging of estimation activity in thyroid associated ophthalmopathy （TAO）. Methods Acording to the clinnic activity score （CAS）, 26 TAO patients were divided into two groups： active group （CAS ≥3） and inactive group （CAS〈3）, 14 volunteers （control group） participates this study. Orbit scan were completed after intravenously injection with ^99Tc^m-DTPA 740 MBq and ^99Tc^m-OCT （every other day）. Obtaining the uptake ratio （UR） of two kinds of orbit scans. The statistical analyses included Paired-samples t test analysis of variance and Spearman regression analysis. Results There is no statistically significance between the two methods in UR （t=0.075, P〉0.05）. There is a statistically significant correlation was found between CAS and the uptake ratios（^99Tc^m-DTPA： r=0.835, P〈0.001 ; ^99Tc^m-OCT： r=0.912, P〈0.001） . Conclusions There is a good uniformity between ^99Tc^m-DTPA and ^99Tc^m-OCT orbital scan; ^99Tc^m-DTPA is a feasible and maybe a new promising estimation method of activity in the patients with TAO.

关 键 词：^99Tc^m-五乙酸盐^99Tc^m-奥曲肽 体层摄影术 发射型计算机 单光子 GRAVES眼病 眼眶 

分 类 号：R77[医药卫生—眼科] R5[医药卫生—临床医学]