胆囊肿瘤组织CA72.4和CA242表达临床意义的研究  

Expressions of carbohydrate CA72.4 and CA242 and clinicopathological significance in benign and malignant lesions of gallbladder

作　　者：苗雄鹰[1] 杨竹林[1] 杨乐平[1] 付汐[1] 

机构地区：[1]中南大学湘雅二医院肝胆胰疾病研究室,湖南长沙410011

出　　处：《中华肿瘤防治杂志》2009年第8期607-609,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨胆囊腺癌、癌旁上皮和慢性胆囊炎组织中CA72.4和CA242表达水平及其临床意义。方法:108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎组织手术切除标本常规石蜡包埋切片,EnVi-sionTM免疫组化法对CA72.4和CA242染色。结果:胆囊腺癌组织中,CA72.4和CA242阳性表达率明显高于癌旁组织和慢性胆囊炎组织的表达率,P<0.01。腺瘤癌变、肿块最大径<2cm、无淋巴结转移和未侵犯周围组织病例的CA72.4和CA242阳性表达率,明显低于低分化腺癌、肿块最大径≥2cm、淋巴结转移及侵犯周围组织病例的表达率,P<0.01;胆囊腺癌组织中两者表达呈高度一致性,χ2=56.24,P<0.01。结论:CA72.4和CA242可作为反映胆囊腺癌进展、生物学行为及预后的重要标志。OBJECTIVE： To study the expressions of CA72.4 and CA242 and explore their clinicopathological significance in gallbladder adenocarcinoma, peritumoral tissues, and chronic choleeystitis. METHODS： EnVision^TM immunohistochemistry was used for detecting the expressive levels of CA72.4 and CA242 in the routinely paraffin embedded sections of the specimens from gallbladder adenocarcinoma （n= 108）, peritnmoral tissues （n=46）, and chronic cholecystitis （n= 35）. RESULTS： The positive rates of CA72.4 and CA242 were significantly higher in gallbladder adenocarcinoma than those in peritumoral tissues and chronic cholecystitis （P〈0. 01）. The positive rates of CA72.4 and CA242 were significantly lower in adenomatous canceration, maximal diameter 〈2 cm, no-metastasis of lymph node and no-invasion regional tissue than those in low differentiated adenocarcinoma, maximal diameter ≥2 cm, lymphnode metastasis and regional tissue invasion （X^2 = 56.24, P〈0. 01）. CONCLUSION ： The expressions of CA72.4 and CA242 may be important biological markers for reflecting the progression, biological behaviors and prognosis of gall bladder adenocarcinoma.

关 键 词：胆囊肿瘤 慢性胆囊炎 糖类抗原类 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]