sICAM-1、sVCAM-1在急性动脉硬化性脑梗死中的临床意义  

The Clinical Significance of sICAM-1、sVCAM-1 in Acute Atherosclerosis Cerebral Infarction

作　　者：王汉旻[1] 陈晓丽[1] 黄海波[1] 金得辛[1] 张旭[1] 夏君慧[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000

出　　处：《心脑血管病防治》2009年第3期170-171,共2页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的:探讨可溶性细胞间黏附分子-1(sICAM-1)及可溶性血管细胞间黏附分子-1(sVCAM-1)在急性动脉硬化性脑梗死中的临床意义。方法:研究对象分为急性脑梗死组(n=60例)及对照组(n=28例),检测所有受试者血清sICAM-1、sVCAM-1水平,分析二者与脑梗死面积及临床转归之间的关系。结果:急性脑梗死患者血清sICAM-1、sVCAM-1水平显著高于对照组(P<0.01),二者与梗死面积大小呈正相关;而不同转归组之间二者含量无显著差别。结论:sICAM-1、sVCAM-1参与脑梗死炎症过程,可预示脑梗死严重程度。Objective:To estimate the Clinical Significance of soluble intercellular adhesion molecule-1(sICAM-1)and soluble Vascular cell adhesion molecule-1(sVCAM-1)in acute atherosclerosis cerebral infarction.Methods:All subjects were divided into acute infarction group(n=60)and control group(n=28).Serum sICAM-1 and sVCAM-1 were determined.We evaluated the association of sICAM-1 and sVCAM-1 with infarct size and prognosis.Results:The values of sICAM-1 and sVCAM-1 were significantly higher in acute infarction group than those in control group(P<0.01).Both had positive correlation with infarct size(P<0.05),but not associated with prognosis after acute infarction(P>0.05).Conclusions:sICAM-1 and sVCAM-1 play a role in inflammation process of cerebral infarction and they can predict cerebral infarction severity.

关 键 词：急性动脉硬化性脑梗死 SICAM-1 SVCAM-1 临床意义 神经细胞凋亡 血液供应障碍 血管内皮细胞 炎性细胞浸润 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R541.4[医药卫生—临床医学]