肝癌基因治疗的进展  

Gene therapy of hepatocellular carcinoma

作　　者：周钟萍[1] 何少健[1] 

机构地区：[1]广西医科大学组织学与胚胎学教研室

出　　处：《中国临床新医学》2009年第5期435-438,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金项目(桂科自0542068);国家教育部高等学校博士学科点专项科研基金(20050598006);国家自然科学基金(3046003);广西高发病创新性团队基金(桂教2007-71)

摘　　要：肝癌是全世界最常见的恶性肿瘤之一，目前缺乏有效的治疗手段，寻找肝癌新的治疗策略显得尤为迫切。基因治疗途径（依赖遗传物质转染细胞如溶瘤病毒、抑癌基因、自杀基因、编码抗血管生成因子基因、小干扰RNA（siRNA）和免疫调节分子基因）为肝癌治疗提供了富有希望的治疗途径，并且已经在肝癌和转移性肝癌的动物模型中进行了大量的实验评估，治疗的载体和基因的多样性，单独或联合应用基因治疗的途径可能在控制肝癌生长方面产生有利的效果。Hepatocellular carcinoma （HCC） is one of the most frequent cancers worldwide. Effective therapy to this cancer is currently lacking, creating an urgent need for new therapeutic strategies for HCC. Gene therapy approach that relies on the transduction of cells with genetic materials, such as oncolytic viral vectors, anti - oncogenes, suicide genes, genes coding for antiangiogenic factors, small interfering RNA（siRNA）, or genes coding for immunomodulatory molecules may provide a promising strategy. The aforementioned strategies have been largely evaluated in the animal models with HCC or liver metastasis. Due to the diversity of vectors and therapeutic genes, being used alone or in combination, gene therapy approach may generate beneficial effects to control the growth of tumors within the liver.

关 键 词：肝癌 基因治疗 

分 类 号：R735.7[医药卫生—肿瘤]