手性化合物的质谱分析研究  

Mass Spectrometry of Chiral Compounds

作　　者：陈耀祖[1,2] 吴忆南[1] 

机构地区：[1]浙江大学有机化学研究所 [2]兰州大学应用有机化学国家重点实验室,兰州730000

出　　处：《分析化学》1998年第6期737-741,共5页Chinese Journal of Analytical Chemistry

摘　　要：运用不含手性碳的非对称化合物Ｓ－ＢＮＰ酸（Ｓ－ｐｈｏｓｐｈｏｒｓａｅｕｒｅ－（１，１＇－ｂｉｎａｐｈｔｈｙｌ－２，２＇－ｄｉｙｌｅｓｔｅｒ））作反应试剂用快原子轰击反应质谱法（ＦＡＢ－ＲＭＳ）测定手性化合物的绝对构型．发现非对称手性化合物可与不对称手性化合物在质谱中发生立体选择性反应，Ｓ－ＢＮＰ酸可作为一种新的反应试剂来测定手性化合物的绝对构型．In fast atom bombardment mass spectrometry (FABMS), the stereochemical effect of dissymmetric compound S-phosphorasaeure- (1, 1' -binaphthyl-2, 2' -diylester) (S-BNP acid) was studied. The dissymmetric compound can react stereoselectively with the enantiomers whose chirality is caused by asymmetric carbon, and S-BNP acid can be used as new reaction reagent for determination of absolute configuration of enantiomer by reaction mass spectrometry.

关 键 词：手性化合物 绝对构型 构型 分析 质谱 

分 类 号：O641.6[理学—物理化学]