宫颈癌中表皮生长因子受体的表达与临床预后的相关性研究  

Expression of epidermal growth factor receptor of cervical carcinoma and its correlation with prognosis.

作　　者：邓玲红[1] 冯淑瑜[1] 康佳丽[1] 张彦娜[2] 林乔儿[1] 聂妙玲[1] 程海燕[2] 孙晋瑞[2] 

机构地区：[1]广东省广州市第一人民医院妇产科,510180 [2]中山大学肿瘤防治中心妇科 华南肿瘤学国家重点实验室

出　　处：《中国综合临床》2009年第6期590-592,共3页Clinical Medicine of China

基　　金：广州医药卫生科技项目（2007-YB-028）

摘　　要：目的研究表皮生长因子受体（EGFR）在宫颈癌及宫颈上皮内瘤样病变（CIN）中的表达，并探讨其与宫颈癌发生、浸润转移及预后的相互关系。方法应用免疫组化法对100例宫颈癌、60例CIN及40例正常宫颈上皮组织中的EGFR进行检测。结果正常上皮、CIN、宫颈癌组织的EGFR过表达率分别为0％（0／40）、51．67％（31／60）、78．00％（78／100）。宫颈癌组的EGFR过表达率显著高于CIN组（P〈0．05，OR=3．32，95％CI：1．67—6．63），2组的EGFR过表达率均显著高于对照组（P均〈0．01）。EGFR过表达与宫颈癌临床分期、肿瘤体积、病理类型、组织分化、宫颈浸润深度、颈管侵犯及淋巴结转移均无显著相关（P均〉0．05），与宫颈癌预后也无显著相关（P〉0．05）。结论在宫颈癌变过程中，EGFR过度表达水平随着宫颈病变程度的加重而上升，提示EGFR过度表达与宫颈肿瘤的发生相关，EGFR可能成为有价值的宫颈癌生物学指标。EGFR过度表达与宫颈癌临床病理特征及预后无关。Objective To study the expression of epidermal growth factor receptor （EGFR） in cervical carcinoma and cervical intraepithelial neoplasia（CIN） ,and to elucidate its relation with the genesis, infiltration, metastasis and prognosis of cervical carcinoma. Methods EGFR was determined by means of S-P immunohistochemistry in tissue of 100 cases of cervical carcinoma,60 cases of CIN and 40 cases of controls. Results The overexpression rates of EGFR were 0% （0/40） ,51.67 % （31/60 ） ,78.00% （78/100） , respectively in normal cervical epithelium, CIN and cervical tumor tissues. The overexpression rate of EGFR was significantly higher in cervical tumor tissue than in CIN（P 〈0.05 ,OR =3.32,95% CI for OR： 1.67-6.63） ,which was significantly higher in both two groups than in control group（ P 〈 0.01 ）. The overexpression of EGFR didn＇t demonstrate significant association with clinical staging, tumor size, pathological type, differentiation, cervical invasion depth, cervical canal invasion, lymphnode metastasis or the prognosis of cervical neoplasm （P 〉 0.05 ）. Conclusion Overexpression of EGFR is worsened with the severity of cervical lesion, suggesting that overexpression of EGFR is correlated with the genesis of cervical neoplasma,which may be a valuable biological indicator of cervical carcinoma,but is not correlated with clinical pathological features and prognosis of cervical carcinoma .

关 键 词：宫颈癌 宫颈上皮内瘤变 表皮生长因子受体 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤] R737.330.2[医药卫生—临床医学]