乳腺癌组织中基质溶解素的表达及其与微血管密度的关系  

Expression of stromlysin in breast cancer tissue and its relationship with microvessel density.

作　　者：赵郁[1] 刘秀清 李颖[3] 尹华[3] 王凤玲[3] 

机构地区：[1]河北省唐山市人民医院放化疗科,063000 [2]乐亭县医院 [3]华北煤炭医学院

出　　处：《中国综合临床》2009年第6期641-643,共3页Clinical Medicine of China

摘　　要：目的研究基质溶解素（MMP-7）和微血管密度（MVD）与乳腺癌临床病理表现特征的关系及MMP-7对乳腺癌MVD的影响。方法选取乳腺癌患者组织标本60例，应用过氧化物酶标记链酶卵白素法（SP法）检测MMP-7和血管内皮细胞CD34的表达，分析MMP-7、MVD与患者年龄、肿瘤大小、组织学类型、淋巴结转移及肿瘤雌激素受体（ER）、催乳素受体（PR）、核增殖抗原（PCNA）、p53、C-erbB-2表达的关系，评价MMP-7、MVD在乳腺癌预后判断中的临床价值。结果直径〉2cm、有淋巴结转移，PCNA、p53、C-erbB-2阳性乳腺癌组织中MMP-7的阳性表达率（78．1％、74．2％、71．8％、67．6％和72．2％）显著高于其在直径≤2cm（32．1％）、无淋巴结转移（41．3％），PCNA（38．1％）、p53（38．5％）、C-erbB-2（33．3％）阴性乳腺癌组织中的阳性表达率（P〈0．05）。MVD在直径〉2cm（34．61±6．97）、有淋巴结转移（34．37±7．50），PCNA（33．24±8．39）、p53（33．28±8．94）、C—erbB-2（33．55±8．57）阳性乳腺癌组织中显著高于其在直径≤2cm（28．60±9．82）、无淋巴结转移（27．48±8．66），PCNA（26．88±7．89）、p53（21．71±7．59）、C-erbB-2（27．42±7．69）阴性乳腺癌组织（P均〈0.05）。MMP-7阳性乳腺癌组织的MVD[（33．62±7．36）个／高倍镜]显著高于MMP-7阴性乳腺癌组织（27．86±9．45）个／高倍镜（P〈0．05），MMP-7阳性表达与MVD相关（r=0．380，P〈0．05）。结论MMP-7和MVD的高表达与乳腺癌的演进和迁移有关，MMP-7具有促进乳腺癌微血管生成的作用。Objective To investigate the relationship between the biological characteristics and the expression of stromlysin （MMP-7） and microvessel density （MVD） in breast cancer tissue and the effect of MMP -7 on MVD of breast cancer. Methods 60 fresh samples were obtained from patients with breast cancer,and then the expression of MMP-7 and vascular endothelial cell CD34 were studied by means of immunohistochemical assay （ SP method）. The relationship between MMP-7, MVD and age, tumor size, histological type, lymph node metastasis and expression of ER, PR, PCNA, p53 and CerbB2 was studied. The relationship between the biological characteristics and the expression of MMP-7 and MVD in breast cancer were evaluated. Results The positive expression rate of MMP-7 in the d 〉 2 cm group, the group with lymph node metastasis, the group with positive expression of PCNA, p53 and C-erbB-2 （78.1% ,74.2% ,71.8% ,67.6% and 72.2% ）were all higher than that in the d≤2 cm group, the group without lymph node metastasis, the group without positive expression of PCNA, p53 and C-erbB-2 （32.1%, 41.3% ,38.1%, 38.5% and 33.3% ） （P 〈 0.05）. MVD was higher in the positive breast cancer tissue of the group of d 〉2 cm（34.61 ±6.97） ,the group with lymph node metastasis（34.37 ±7.50） ,PCNA（33.24 ± 8.39）, p53 （33.28±8.94 ）, C-erbB-2 （33.55 ± 8.57 ） than in the negative breast cancer tissue of the d ≤ 2 cm group （28.60 ±9.82 ）, the group without lymph node metastasis（27.48 ± 8.66 ）, PCNA （26.88 ±7.89 ）, p53 （21.71 ± 7.59）, C-erbB-2 （27.42± 27.69 ） （ P 〈 0. 05 ）. MVD （ 33.62 ± 7.36 ） / high power lens in the MMP-7 positive group was higher than that （27.86 ±9.45 ）/high power lens in the MMP-7 of negative group（P 〈0.05）. The positive expression of MMP-7 was correlated with MVD （ r = 0. 380, P 〈 0.05 ）. Conclusion The high expression of MMP-7 and MVD is associated with the development and metastasis of breast cancer. MMP-7 could promote the microv

关 键 词：乳腺癌 基质溶解素 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤] R735.702[医药卫生—临床医学]