贝诺酯的合成工艺改进  

Improved Synthesis of Benorilate

作　　者：陈旭冰[1] 陈光勇[1] 施贵荣[1] 刘光明[1] 

机构地区：[1]大理学院药学院,云南大理671000

出　　处：《大理学院学报（综合版）》2009年第6期12-14,共3页Journal of Dali University

基　　金：大理学院本科应用型示范课程--药物化学(大院教发[2008]7号)

摘　　要：目的:优化贝诺酯的合成方法。方法:在合成乙酰水杨酰氯时以DMF为催化剂,然后溴化四丁基铵为相转移催化剂酯化而得贝诺酯。结果:合成了贝诺酯,总收率为90.8%。结论:本方法反应条件温和,操作简便,且提高了反应收率。Objective：To optimize the synthetic method of benorilate. Methods：When acetylsalicylryl chloride was synthesized, DMF as catalysis was added and benorilate was obtained in the presence of tetrabutyl ammonium bromide phase transfer catalyst. Results： Benorilate was synthesized with an overall yield of 90.8%. Conclusion：This synthetic route had a mild reaction condition and improved yield, and was easily controlled.

关 键 词：贝诺酯 合成方法 溴化四丁基铵 

分 类 号：R914.4[医药卫生—药物化学]