平阳霉素与高聚金葡素治疗恶性胸腔积液的疗效比较  

Comparison of pingyangmycin and highly agglutinative staphylococcin pleurodesis for malignant pleural effusion

作　　者：祝清清[1] 孙耕耘[1] 

机构地区：[1]安徽医科大学第一附属医院呼吸内科,合肥230022

出　　处：《临床肺科杂志》2009年第7期914-915,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察平阳霉素与高聚金葡素治疗恶性胸腔积液的疗效。方法40例恶性胸腔积液患者随机分为两组,分别给予平阳霉素、高聚金葡素治疗,治疗结束后按WHO统一标准观察患者胸腔积液的变化,评价有效率。结果平阳霉素组治疗有效率55%,高聚金葡素组治疗有效率为85%,两组比较差异有统计学意义(P<0.05)。结论平阳霉素与高聚金葡素胸膜腔内注射对恶性胸腔积液治疗都有一定疗效,高聚金葡素的疗效高于平阳霉素。Objective To observe and compare the effectiveness of pingyangmeyin （PYM） and highly agglutinative staphylococein （HAS） in treating malignant pleural effusion. Methods After complete drainage of pleural fluid, the 40 patients were allocated randomly to receive PYM or HAS by intrapleural injection. One month later, we will evaluate the pleuredesis efficacy according to WHO standard. Results The rates of objective treatment response（ complete response plus partial response） were significantly higher in HAS group than in PYM group （85 % for HAS and 55 % for PYM）. Conclusion Intrapleural HAS injection is seemed to be better choose in the treatment of malignant pleural effusion than intrapleural PYM injection.

关 键 词：平阳霉素 高聚金葡素 恶性胸腔积液 

分 类 号：R730.5[医药卫生—肿瘤]