胆囊癌组织中p53过表达和Ki-67表达与预后的关系  

p53 protein overexpression and Ki -67 antigen expression as prognostic markers in gallbladder carcinoma

作　　者：井小会[1] 吴会战[1] 王俊宽[1] 

机构地区：[1]河南省平顶山市第一人民医院,467000

出　　处：《中国实用医刊》2009年第12期32-33,35,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨p53过表达和Ki-67表达与胆囊癌患者预后的相关性。方法41例标本全部经过术后病理诊断为胆囊癌。所有患者均未行术前放化疗。由于肿瘤分期较旱或者患者身体状况差等原因，所有患者仅行胆囊切除术。采用免疫组织化学ABC法检测标本中P53及Ki-67表达情况。结果29例（71％）胆囊癌组织中p53过表达，过表达p53的患者5年生存率为17．2％，而无过表达的患者为30％，两者差异无统计学意义。24例（58．5％）胆囊癌Ki-67表达阳性，这些患者的5年生存率为9．2％，而无Ki-67表达的患者为27．7％，两者差异无统计学意义。p53过表达和Ki-67表达与细胞分化程度及肿瘤的浸润深度均无相关性。结论p53过表达和Ki-67表达与组织分化程度、胆囊壁浸润深度及患者的预后均无相关性。Objective To investigate the interrelationship between the overexpression of p53 protein and the expression of Ki - 67 antigen and the survival of patients with gallbladder carcinoma.Methods Forty - one surgical specimens from patients with a postoperative histological diagnosis of gallbladder carcinoma were studied. All patients were operated by simple cholecystectomy only because the tumours were not advanced and/or their general condition was poor. The expression of p53 and Ki -67 was measured by immunohistochemistry. Results Twenty -nine gallbladder carcinomas （71%） overexpressed p53 protein. Five - year survival of patients with gallbladder carcinoma overexpressing p53 was 17.2%, while survival of patients without p53 overexpression was 30% （ not significant）. Twenty - four cases （58.5%） were considered positive for the MIB - I index. Five - year survival of the patients with a MIB - 1 positive index was 9.2% as opposed to 27.7% for those with a negative index （ not significant）. There were no differences between the grade of cell differentiation and wall infiltration. Conclusions p53 protein overexpression and Ki -67 protein expression in gallbladder carcinoma are not related to histological differentiation, level of gallbladder wall invasion or patient survival.

关 键 词：胆囊癌 P53 KI-67 

分 类 号：R735.8[医药卫生—肿瘤]