Dysferlin在子痫前期胎盘中的表达  

Expression of Dysferlin in placenta in patients with pre-eclampsia

作　　者：黄小玲[1] 王自能[1] 

机构地区：[1]暨南大学附属第一医院妇产科,广州市510630

出　　处：《实用医学杂志》2009年第11期1767-1768,共2页The Journal of Practical Medicine

摘　　要：目的:探讨Dysferlin在子痫前期(preeclampsia,PE)胎盘中的表达及可能意义。方法:随机选择PE患者20例,其中轻度PE10例(轻度PE组),重度PE10例(重度PE组),正常对照10例(对照组),取其胎盘中央母体面组织制成石蜡块。用免疫组化SP法观察Dysferlin在各组胎盘的表达及分布,并作定量分析。结果:Dysferlin在胎盘绒毛合体滋养细胞层表达阳性,亦在内皮细胞出现阳性表达。其表达强度在对照组为27.31±14.09,轻度PE组为39.64±17.29,重度PE组为48.35±12.83,各组间的表达差异有统计学意义(P<0.05)。结论:Dysferlin在胎盘表达阳性,可能跟PE发病有关,并随病情加重表达增强。Objective To detect the expression of Dysferlin in placenta in patients with pre-eclampsia. Methods Expression of Dysferlin was detected by immunohistochemical SP method in placental tissue from 20 women with pre-eclampsia [ 10 were mild （mild group） and 10 were severe （severe group）] and 10 women with normal pregnancy （control group）. Results Dysferlin was positively expressed in syneytiotrophoblasts and endothelial cells of placenta. There were significant differences of the expressive rate of Dysferlin in placenta tissue among the 3 groups [ control group vs mild group vs severe group： （27.31 ±14.09） vs （39.64 ±17.29） vs （ 48.35 ±12.83）, P 〈 0.05]. Conclusion Dysferlin is positively expressed in placenta, and may play a role in the pathogenesis of pre-eclampsia.

关 键 词：先兆子痫 DYSFERLIN 免疫组化 

分 类 号：R714.2[医药卫生—妇产科学]