HPV各亚型在新疆各地区维吾尔族宫颈癌患者中的分布研究  

Study on distribution of HPV subtypes in Uygur women with cervical cancer from every region of Xinjiang

作　　者：古扎丽努尔.阿不力孜 帕提曼.米吉提 李庭芳[3] 程静新[2] 李华[1] 路玲[1] 

机构地区：[1]新疆医科大学附属肿瘤医院妇外五科,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院妇外三科,新疆乌鲁木齐830011 [3]新疆医科大学附属肿瘤医院妇外四科,新疆乌鲁木齐830011

出　　处：《新疆医科大学学报》2009年第5期513-517,共5页Journal of Xinjiang Medical University

基　　金：国家自然科学基金项目(30360107);新疆维吾尔自治区高校科研计划科学研究重点项目(XJED2004132)

摘　　要：目的:探讨HPV(Human papiloma virus,人乳头瘤病毒)各亚型在新疆维吾尔族宫颈癌患者中的分布情况,及HPV感染与新疆维吾尔族宫颈癌临床分期、病理类型及分化程度的关系,从而为新疆维吾尔族宫颈癌疫苗的研究及使用提供理论依据。方法:通过凯普导流杂交HPVDNA检测法(flow-through hybridization and gene chip,简称HybriMax),对350例维吾尔族宫颈癌患者宫颈组织进行21种HPV亚型的检测。结果:(1)新疆各地区维吾尔族宫颈癌HPV总阳性率为83.14%;HPV各亚型在新疆HPV阳性的宫颈癌组织中出现的频率排序为:HPV16(91.75%)、18(6.19%)、68(3.44%)、45(3.44%)、58(3.09%)、39(1.72%)、31(1.37%)、56(1.37%)、59(0.34%)、53(0.34%)、6(0.34%),其它亚型未检测出。(2)喀什等三个南疆地区宫颈癌HPV阳性率及HPV16阳性率与乌鲁木齐等其他地区宫颈癌HPV阳性率及HPV16阳性率之间差异无统计学意义(P>0.05)。(3)临床Ⅰ～Ⅱ期及Ⅲ～Ⅳ期宫颈癌和各分化程度之间的HPV阳性率差异无显著性(P>0.05)。鳞癌及其它病理类型宫颈癌HPV阳性率明显高于腺癌,差异有统计学意义(P<0.05)。结论:新疆宫颈癌各地区均有较高的HPV阳性率,各地区HPV及HPV16阳性率之间无差异,HPV16在各地区均排在首位,HPV18虽然在第二位,但阳性率明显低于文献报道,排在第三位的HPV68及HPV45与国内外各亚型的分布状况有所不同。HPV感染与维吾尔族宫颈癌的临床分期、分化程度无关,与病理类型有关。Objective： Investigate the distribution of Human papilloma virus （HPV） subtypes in the Xinjiang Uygur cervical cancer patients, and the relation between HPV infection with clinical stages, pathological types and cell differentiations degree, provide theory bases for research on Xinjiang HPV vaccine. Method. To detect the 21 subtypes of HPV from 350 cases of cervical carcinomas, by using flow-through hybridization and gene chip technology. Results： （1） 291 cases were detected to be HPV positive in 350 cases Xinjiang Uygur cervical cancer patients, HPV-positive rate was 83.14%, the order of frequency of HPV subtypes in Xinjiang Uygur cervical cancer are： HPV16, 18, 68, 45, 58, 39, 31, 56, 59, 53, 6, other subtypes are not detected out. （2） There was no statistical differences between southern and else region in Xinjiang of the positive rate of HPV and HPV16. （3） HPV positive rate were no statistical differences in clinical stages Ⅰ～Ⅱ and Ⅲ～Ⅳ （P〉0.05） ; there has no statistical differences between differentiations degree （P〉0.05）. Squamous cancer, other pathological types has statistical differences with adenocarcinoma tissue respectively （P〈0.05）. Conclusions： HPV positive rate were very high in Xinjiang regions, HPV16 positive rate is the highest, HPV18 follows it, and the positive rate is much lower than other reports; HPV68 and HPV45 are at the third place, this is different from HPVsubtypes distribution in other region. HPV infection was not related to the clinical stages and differentiations degree of cervical cancer, but related to the pathological types of cervical cancer.

关 键 词：人乳头瘤病毒 宫颈癌 新疆 维吾尔族 HPV疫苗 

分 类 号：R737.33[医药卫生—肿瘤]