新疆维吾尔族妇女宫颈癌与人乳头状瘤病毒多重感染的关系研究  

The study of the relationships between HPV multiple infection and cervical cancer of Uygur Women in Xinjiang

作　　者：张苏琴[1] 库尔班尼沙.亚合浦 古扎丽努尔.阿不力孜 古丽沙热.纳依木 古扎丽努尔.阿不都西库尔 唐努尔.阿不力米提 

机构地区：[1]新疆医科大学附属肿瘤医院妇外五科,新疆乌鲁木齐830011 [2]新疆喀什地区妇幼保健医院,新疆喀什844000

出　　处：《新疆医科大学学报》2009年第5期525-528,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金项目(30360107);新疆维吾尔自治区高校科研计划科学研究重点项目(XJED2004132)

摘　　要：目的:探讨人乳头状瘤病毒(Human papillomavirus,HPV)多重感染与新疆维吾尔族妇女宫颈癌的关系。方法:采用导流杂交基因芯片技术对350例新疆维吾尔族宫颈癌患者(宫颈癌组)及100例正常妇女(对照组)宫颈组织中HPV的21种亚型进行检测。结果:350例宫颈癌组织中HPV阳性者291例(包括单一感染及多重感染),阳性率为83.14%。其中HPV单一感染者255例,占宫颈癌患者的72.86%,占HPV阳性宫颈癌的87.63%;而多重感染者36例,占宫颈癌患者的10.29%,占HPV阳性宫颈癌的12.37%。HPV的多重感染中以二重感染为主,占多重感染的91.67%,多重感染的类型以HPV16为主,占多重感染的97.22%。对照组中HPV阳性率为7.00%,其中单一感染者6例,二重感染者1例。两组多重感染率宫颈癌组明显高于对照组,差异有统计学意义(P<0.01)。HPV多重感染在各病理类型的宫颈癌中的分布比例差异无显著性(P>0.05)。HPV多重感染在Ⅰ～Ⅱ期及Ⅲ～Ⅳ期中的分布比例差异无统计学意义。结论:新疆维吾尔族宫颈癌多重感染的类型以HPV16感染为主,多重感染与宫颈癌的病理类型及临床期别无关;多重感染中以二重感染为主,即HPV16与其他类型合并感染,但多重感染的比例较低,类型较单一,这可能与此民族基本居住在新疆,移动较少、与其他民族同婚极少、遗传背景、生活习惯及居住环境等因素有关。Objective： To study the relationships between HPV multiple infection and cervical cancer in Xin-jiang Uygur Women. Method： To detect 21 subtypes of HPV from 350 cervical cancer cases and 100 normal tissues, by using flow-through hybridization and gene chip （HybriMax） method. Results： The positive rate of HPV in cervical cancer and control group were 83.14% （include simple and multiple infection） and 7.0% respectively; Among cervical cancer there are 255 cases of simple infection with the rate of 72.86% （255/350）, and it occupies 87.63% （255/291） of HPV positive cancer. There were 36 cases of multiple in-fection ,it occupies the 10.29% （36/350） of cervical cancer patients and 12.37% （36/291） of HPV positive cancer patients. Two types combined infection was common it occupies 91.67%（33/35） of multiple infection; The HPV16 combined infection with other types were common and it occupies 97.22% （35/36） of multiple infection. The positive rate of HPV in control group was 7.0%（7/100）, among them there 6 cases of simple infection （6.0 %） and one case of multiple infection （1.0 %）. The positive rate of multiple in-fection of cervical cancer group were significantly higher than that in control group （P〈0.01）. The posi- tive rate of multiple infection in different clinical stages and pathological types has no statistical differences （P 〉0.05）. Conclusions： The HPV16 were common in multiple infection, two types combined infection were common; HPV16 combined infection with other types were common in multiple infection. But the rate of multiple infection were low and the multiple infection shows its simplarity, These may be associated

关 键 词：宫颈癌 维吾尔族 人乳头状瘤病毒 多重感染 导流杂交基因芯片技术 

分 类 号：R737.33[医药卫生—肿瘤]