非编码RNA与人类重大疾病的发生及其在生物医学领域内的应用  

Relationship between noncoding RNA and pathogenesis of major human diseases and its application in biomedicine

作　　者：郭艳合[1] 张义玲[1] 刘立[1] 蔡荣[1] 钱程[1] 

机构地区：[1]浙江理工大学生命科学学院,新元医学与生物技术研究所,浙江杭州310018

出　　处：《中国病理生理杂志》2009年第6期1232-1239,共8页Chinese Journal of Pathophysiology

基　　金：973国家重点基础研究发展计划基金资助项目(No.2004CB518804);863高科技发展基金资助项目(No.2006AA02Z126);浙江省社会发展重点资助项目(No.2006C23006)

摘　　要：Noncoding RNA(ncRNA) is a kind of transcripts without the ability of coding proteins,which exist widely in highly eukaryotic.The amount of the ncRNA transcripts is up to 98% of the whole genome’s transcripts.The difference in molecular structure and expressive pattern from other kinds of RNA endows them specific biological functions.Although exact functions of most ncRNA are not well known,it has been demonstrated that ncRNA was associated with some major human diseases.It would be helpful to design effective therapeutic strategies,if we understand how ncRNA is involved in the pathogenesis of human major diseases.This review will shed light on the expressive pattern and distribution of ncRNA,the relationship between diseases and ncRNA and finally the application of ncRNA in the therapeutic fields.Noncoding RNA （ncRNA） is a kind of transcripts without the ability of coding proteins, which exist widely in highly eukaryotic. The amount of the ncRNA transcripts is up to 98% of the whole genome＇ s transcripts. The difference in molecular structure and expressive pattern from other kinds of RNA endows them specific biological functions. Although exact functions of most ncRNA are not well known, it has been demonstrated that ncRNA was associated with some major human diseases. It would be helpful to design effective therapeutic strategies, if we understand how ncRNA is involved in the pathogenesis of human major diseases. This review will shed light on the expressive pattern and distribution of ncRNA, the relationship between diseases and ncRNA and finally the application of ncRNA in the therapeutic fields.

关 键 词：非编码RNA 神经系统疾病 肿瘤 调节RNA 

分 类 号：R394[医药卫生—医学遗传学]