类黄酮抗癌作用机制的研究进展  

Updated anti-cancer mechanism of flavonoids

作　　者：陆晓和[1] 金念祖[2] 

机构地区：[1]南京军区南京总医院药学部,江苏南京210002 [2]南京医科大学公共卫生学院,江苏南京210029

出　　处：《医学研究生学报》2009年第5期536-539,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30572133)

摘　　要：类黄酮尽管在体外试验中表现出很强的抗氧化能力,但由于在人体血浆中的稳态浓度低,所以作为抗氧化剂产生的抗癌作用是较小的。类黄酮预防癌症的作用主要与其调控细胞周期、诱导细胞凋亡、抑制血管发生和调节细胞内的信号级联放大等干涉细胞基本功能的作用机制有关。Flavonoids, despite their strong antioxidant capacity in vitro 斜体, have low steady-state concentrations in human plasma, and thus, as antioxidants, have very little anti-cancer effect. Their cancer preventing effect can be attributed mainly to their ability to interact with basic cellular mechanisms. Such interactions include induction of cell cycle arrest and apoptosis, inhibition of angiogenesis, modulation of signaling cascades, and so on.

关 键 词：类黄酮 癌症 预防 抗氧化剂 

分 类 号：R979.1[医药卫生—药品]