大肠癌组织中COX-2，iNOS，VEGF的表达及其临床意义  

Expression of inducible nitric oxide synthase, cyclooxygenase-2and Vascular endothelial growth factor in human colorectal carcinoma and Their Clinical Significances

作　　者：姚卫康[1] 包建荣[2] 冯一中[3] 顾丽琴[2] 杜锋[1] 章仁华[1] 

机构地区：[1]江苏省太仓市中医院普外科,215400 [2]江苏省太仓市中医院病理科,215400 [3]苏州大学附属第二医院病理科

出　　处：《中国临床实用医学》2009年第6期3-4,共2页China Clinical Practical Medicine

基　　金：苏州市社会发展项目;太仓市高层次人才资助项目（项目编号：[2006]005号）

摘　　要：目的探讨COX-2，iNOS，VEGF在大肠癌组织中的表达及其临床意义。方法采用免疫组化方法检测58例大肠癌组织中COX-2，iNOS，VEGF的表达，并分析其临床意义。结果58例大肠癌组织中COX-2，iNOS，VEGF的阳性表达率分别为79．31％（46／58）、84．48％（49／58）和79．31％（46／58），显著高于正常大肠组织（P〈0．01），与患者年龄、有无淋巴结转移、肿瘤体积及组织学类型差异无统计学意义（P〉0．05），COX-2与VEGF的表达存在一定相关性（P〈0．05），COX-2与iNOS的表达也存在一定相关性（P〈0．05）。结论大肠癌组织COX-2、iNOS的表达与肿瘤血管生成密切相关，二者可能与VEGF协同促进肿瘤血管生成，是判断肿瘤恶性程度及预后的的重要生物学指标。Objective To investigate expression of inducible nitric oxide synthase, cyclooxygenase- 2and Vascular endothelial growth factor in human colorectal carcinoma and their clinical significances. Methods The expressions of COX-2, iNOS, VEGF in 58 casees of colorectal carcinoma tissue were assessed by immuno- histochemistry, and there relation to there clinical significance were statistically analyzed. Results Positive ex- pression rates of COX-2, iNOS, VEGF in 58 casees of colorectal carcinoma tissue were79. 31% （46/58）, 84.48% （49/58）, 79.31% （46/58）, which were significantly higher than that in colorectal tissues, the expres- sions of COX-2, iNOS, VEGF donnot relate to age,lymph node status and the structural type of colorectal carci- noma（P 〉 0. 05 ）. The expression of COX-2was correlated with VEGF and iNOS. （ P 〈 0. 05 ）. Conclusion COX-2,iNOS may promote angiogenesis through the way of VEGF, they may be important biological markers in evaluateing the malignant degree and prognosis.

关 键 词：大肠癌 COX-2 INOS VEGF 免疫组化 

分 类 号：R735.34[医药卫生—肿瘤]