文拉法辛合并舒必利治疗抑郁症的随机对照研究  

The Comparative Study of Venlafaxine Combined with Sulpiride for Treating Patients with Depression

作　　者：尹定富 曹秀英[1] 周建文[1] 

机构地区：[1]湖北省黄石市精神病医院,435004

出　　处：《中国临床实用医学》2009年第6期32-33,共2页China Clinical Practical Medicine

摘　　要：目的观察文拉法辛合并舒必利治疗抑郁症的疗效和不良反应。方法对64例住院的抑郁症患者随机分为两组，研究组给予文拉法辛合并舒必利治疗，对照组单用文拉法辛治疗，采用汉密尔顿抑郁量表（HAMD）及副反应量表（TESS）评定疗效和不良反应。结果研究组第一周HAMD减分率33．08％显著高于对照组10．64％，四周后研究组显效率87．5％优于对照组68．8％，两组均无严重不良反应。结论文拉法辛合并舒必利能快速缓解抑郁症状，疗效优于单用文拉法辛，不良反应不增加，患者依从性好。Objective To observe the curative effect and adverse reaction in the treatment of depres- sion by using venlafaxine combined with sulpiride. Methods The 64 hospital patients with depression were di- vided into two groups randomly. The study group of patients was treated with Venlafaxine Combined with Sulpiride while the controlled group of patients was treated with venlafaxine only. The curative effect and adverse reaction will be measured by Hamilton Depression Scale （HAMD） and Treatment Emergent Symptom Scale （TESS）. Results The decrease rate in HAMD of the study group33.08% is higher than the controlled groupl0. 64% from the first week and the curative effect87. 5% is better than the controlled group68.8% from the fourth week, there are no badly adverse reaction in two groups. Conclusion The treatment with venlafaxine combined with sulpiride can swiftly relieve the depression symptom and the curative effect is better than the treatment with venlafaxine only, and there is no increasing adverse reaction and the patients are willing to follow the course of treatment.

关 键 词：文拉法辛 舒必利 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]