艾司西酞普兰与帕罗西汀治疗抑郁症对照研究  

A controlled study in the treatment of depression with escitalopram and paroxetine

作　　者：刘小兵[1] 张雅红[1] 谭庆荣[1] 陈云春[1] 王志忠[1] 聂丹[1] 

机构地区：[1]第四军医大学西京医院心身科,西安710032

出　　处：《临床精神医学杂志》2009年第3期177-178,共2页Journal of Clinical Psychiatry

基　　金：国家自然科学基金资助项目(30670758);全军医学科研"十一五"计划科技攻关项目(06G096)

摘　　要：目的:探讨艾司西酞普兰对抑郁症的疗效和安全性。方法:80例抑郁发作患者随机分为艾司西酞普兰组和帕罗西汀组,每组40例,分别给予艾司西酞普兰和帕罗西汀治疗,疗程6周。以汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效;以治疗中出现的症状量表(TESS)评定不良反应。结果:治疗1～2周,艾司西酞普兰组HAMD、HAMA评分均较帕罗西汀组显著下降(P均<0.05),治疗4～6周,两组相仿(P>0.05)。艾司西酞普兰组有效率和治愈率分别为75.7%和54.1%;帕罗西汀组有效率和治愈率分别为80.6%和61.1%;两组差异无显著性(P>0.05)。艾司西酞普兰组不良反应总发生率21.6%,较帕罗西汀组44.4%显著为低(P<0.05)。结论:艾司西酞普兰治疗抑郁症疗效与帕罗西汀相似,安全有效,不良反应较轻。Objective： To study the efficacy and safety of escitalopram in the treatment of major depre- sion. Method：This was a randomized 6 weeks study,80 outpatients and inpatients diagnosed as depression were randomly assigned into escitalopram group with escitalopram （n = 38） and paroxetine group with paroxetine （n = 37 ）. Clinical efficacy was evaluated using Hamilton depression scale（HAMD） and Hamilton anxiety scale （HAMA）, and adverse reactions and safety were assessed with treatment emergent symptom scale （TESS）. Results：The mean values of HAMD and HAMA total scores in the study group was significantly lower than that in the control group at the end of the first two weeks（ all P 〈0.05 ） ,but there was no significant differences be- tween the two groups at the end of week 4,6（ P 〉 0.05）. The response rate and remission rate were 75.7% and 54.1% for escitalopram group and were 80.6% and 61.1% for paroxetine group respectively,There was no sig- nificant difference between two groups （P 〉 O. 05 ）. The total incidence rates of side effect in paroxetine group were higher than that in escitalopram group （ P 〈 0.05 ）. Conclusion ： Escitalopram and paroxetine have sim- ilar effects on major depression. However,escitalopram has less side effects.

关 键 词：抑郁症 艾司西酞普兰 帕罗西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]