奎硫平联合舒必利治疗精神分裂症对照研究  

Controlled study on schizophrenia treated with quetiapine combined with sulpiride

作　　者：寻知元[1] 王丽莉[1] 雷彤[1] 张国双[1] 

机构地区：[1]天津市安定医院,300074

出　　处：《临床精神医学杂志》2009年第3期192-193,共2页Journal of Clinical Psychiatry

摘　　要：目的:比较奎硫平联合舒必利与单用舒必利治疗经奎硫平治疗无效的精神分裂症的疗效和安全性。方法:105例患者随机分为两组,合用组52例,给予奎硫平联合舒必利治疗;单用组53例,单用舒必利治疗。疗程均8周。于治疗前及治疗2、4、8周,采用阳性与阴性症状量表(PANSS)评定临床疗效;采用治疗中出现的症状量表(TESS)评定药物的安全性。结果:治疗2～4周,两组PANSS总分及各因子分均较治疗前显著下降(P<0.05或P<0.01);合用组有效率73.1%,单用组有效率64.2%(P>0.05)。结论:奎硫平联合舒必利与单用舒必利治疗对奎硫平无效的精神分裂症疗效相仿。Objective： To compare the efficacy and safety of quetiapine combined with sulpiride in the treatment of schizophrenia. Method：Patients with schizophrenia who had few response to quetiapine were randomly divided into two groups. One group were treated with quetiapine combined with sulpiride, and the oth- er group with sulpiride only. The treatment duration was 8 weeks. At the beginning and at the end of 2nd,4th, 8th week , all the patients were evaluated with the positive and negative symptoms scale（PANSS） and the treat- ment emergent symptom scale （TESS） to assess the efficacy and side effects respectively. Results：The total score and factor scores of PANSS decreased significantly in both groups after 2 ~4 weeks treatments（ P 〈0.05 or P 〈0.01 ）. The effective rates were 73.1% in combined group and 64.2% in sulpifide group. There was no significant difference in the efficacy between two groups. Conclusion： Quetiapine combined with sulpifide is as effective as sulpiride in the treatment of schizophrenia with few response to quetiapine.

关 键 词：精神分裂症 奎硫平 舒必利 

分 类 号：R749.3[医药卫生—神经病学与精神病学]