瘦素与结直肠腺癌细胞凋亡的关系  

The relationship between leptin and cell apoptosis of colorectal carcinoma

作　　者：董淑慧[1] 高玉彤[1] 潘彦珞[1] 

机构地区：[1]天津市天和医院病理科,天津300050

出　　处：《安徽医药》2009年第6期628-630,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨瘦素(Leptin)在结直肠腺癌发生过程中所起的作用以及与细胞凋亡的相关性,旨在进一步研究结直肠腺癌的发生机制。方法采用免疫组化SP法检测结直肠腺癌、结肠腺瘤和正常结肠上皮细胞中瘦素(Leptin)以及象征凋亡的蛋白质Caspase-3的表达,分析其相关性及与临床病理参数的关系。结果Leptin在结直肠腺癌、结肠腺瘤和正常结肠上皮细胞中的表达与Caspase-3的表达呈现出相反的趋势。结论Leptin作为凋亡抑制剂之一在结直肠腺癌特别是高中分化结直肠腺癌的发生过程中发挥作用。Aim To approach the function of leptin during the carcinogenesis process of colorectal carcinoma, its relationship with cell apoptosis, aimed to make further study about the mechanisms of colorectal carcinogenesis. Methods Immunohistochemistry streptavidinperoxidase method was performed in detecting the expression of the two proteins above in colorectal carcinoma, adenoma of colon and normal colonic epithelial cells. Their relationship was analyzed and their positive expression rates were compared with clinicopathological parameters. Results The expressions of leptin and Caspase-3 showed an opposite trend. Conclusion Leptin reacted as an apoptosis inhibiting factor in the formation of colorectal carcinoma, especially well- and moderately differentiated colorectal adenocarcinoma.

关 键 词：瘦素 CASPASE-3 细胞凋亡 结直肠腺癌 

分 类 号：R735.3[医药卫生—肿瘤] R73-36[医药卫生—临床医学]